Home > Name List By other > (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16, 17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

CAS No 50-27-1 , (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,
17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

  • Name: (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,
    17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
  • Synonyms: Oestriolum; Estratriol;(8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,
    17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol; Ovestin;Oestriol; Theelol; Ovestrion; Tridestrin; Deuslon-A; Trihydroxyestrin;
  • CAS Registry Number:
  • Transport: 5kgs
  • Melting Point: 281-282 ºC
  • Density: 1.255g/cm3
  • Refractive index: 1.624
  • Water Solubility: Insoluble
  • Safety Statements: 53-22-36/37/39-45-36/37
  • Hazard Symbols: T: Toxic;
  • EINECS: 200-022-2
  • Molecular Weight: 288.38136
  • InchiKey: PROQIPRRNZUXQM-ZXXIGWHRSA-N
  • InChI: InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16
    (20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,
    18+/m1/s1
  • Risk Statements: 60-61-40-45
  • Molecular Formula: C18H24O3
  • Molecular Structure:CAS No:50-27-1 (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,<br />17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

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References of (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,
17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
Title: Estriol
CAS Registry Number: 50-27-1
CAS Name: (16a,17b)-Estra-1,3,5(10)-triene-3,16,17-triol
Synonyms: 1,3,5-estratriene-3b,16a,17b-triol; 3,16a,17b-trihydroxy-D1,3,5-estratriene; 16a-hydroxyestradiol; follicular hormone hydrate; oestriol; trihydroxyestrin
Trademarks: Aacifemine (Aaciphar); Colpogyn (Angelini); Destriol; Gyn?san (Bastian); Hormomed (Merckle); Klimax E (Fink); Oekolp (Kade); Ortho-Gynest (Cilag); Ovesterin; Ovestin (Organon); Ovo-Vinces (Wolff); Theelol (Parke-Davis); Trophicreme (Sanofi Winthrop); Tridestrin; Triovex
Molecular Formula: C18H24O3
Molecular Weight: 288.38
Percent Composition: C 74.97%, H 8.39%, O 16.64%
Literature References: A metabolite of, and considerably less potent than the hormone estradiol, q.v. It is usually the predominant estrogenic metabolite found in urine. During pregnancy the placenta produces relatively large amounts of estriol. Isoln from human pregnancy urine: Marrian, Biochem. J. 23, 1090, 1233 (1929); probably occurs as a glycuronide: Cohen, Marrian, ibid. 29, 1577 (1935). Isoln from human placenta: Collip, Br. Med. J. II, 1080 (1930); Collip et al., Endocrinology 18, 71 (1934). Also obtained from plant sources. Isoln from pussywillows: Skarzynski, Nature 131, 766 (1933). Structure: Huffman, Lott, J. Am. Chem. Soc. 69, 1835 (1947). Crystal and molecular structure: Cooper et al., Acta Crystallogr. 25B, 814 (1969). Soly studies: Ruchelman, Howe, J. Chromatogr. Sci. 7, 340 (1969). Partial synthesis: Huffman, J. Biol. Chem. 169, 167 (1947). Syntheses: Huffman, Lott, J. Am. Chem. Soc. 71, 719 (1949); Leeds et al., ibid. 76, 2943 (1954).
Properties: Very small, monoclinic crystals from dil alc. d 1.27. mp 282°. During heating on the microscope heating stage, rearrangement of the crystal structure takes place at 270° and 275° (rate of heating, 4°/min, Kofler microscope heating stage). [a]D25 +58° ±5° (0.04 g in 1 ml dioxane). uv max: 280 nm. Precipitated by digitonin. Practically insol in water. Sol in alcohol, dioxane, chloroform, ether, vegetable oils; freely sol in pyridine, in solns of fixed alkali hydroxides.
Melting point: mp 282°
Optical Rotation: [a]D25 +58° ±5° (0.04 g in 1 ml dioxane)
Absorption maximum: uv max: 280 nm
Density: d 1.27
 
Derivative Type: Triacetate
Molecular Formula: C24H30O6
Molecular Weight: 414.49
Percent Composition: C 69.54%, H 7.30%, O 23.16%
Properties: Crystals from 90% alc. mp 126°.
Melting point: mp 126°
 
Derivative Type: 16,17-Bis(sodium hemisuccinate)
CAS Registry Number: 113-22-4
Synonyms: Estriol succinate
Trademarks: Orgastyptin (Organon); Stiptanon (Organon); Synapause (Organon)
Molecular Formula: C26H30Na2O9
Molecular Weight: 532.49
Percent Composition: C 58.64%, H 5.68%, Na 8.63%, O 27.04%
Literature References: Prepn: GB 879014 (1960 to Organon).
 
Therap-Cat: Estrogen.
Therap-Cat-Vet: Estrogenic hormone therapy.
Keywords: Estrogen; Steroidal.