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CAS No 49564-56-9 , (E)-bis(3-methyl-2-phenylimidazo[1,
2-a]pyridin-4-ium-1-yl)diazene

  • Name: (E)-bis(3-methyl-2-phenylimidazo[1,
    2-a]pyridin-4-ium-1-yl)diazene
  • Synonyms: Fazadinium bromide (INN); SureCN548003; 49564-56-9; D07273; AH-8165D; CHEMBL1697835;dibromide;(E)-bis(3-methyl-2-phenylimidazo[1,
    2-a]pyridin-4-ium-1-yl)diazene; AH-8165; AC1O426S;Fazadinium bromide;
  • CAS Registry Number:
  • Transport: 3249
  • EINECS: 256-378-4
  • Molecular Weight: 604.33836
  • InchiKey: LBOZSXSPRGACHC-NFOZGECASA-L
  • InChI: InChI=1S/C28H24N6.2BrH/c1-21-27(23-13-5-3-6-14-23)33(25-17-9-11-19-31
    (21)25)29-30-34-26-18-10-12-20-32(26)22(2)28(34)24-15-7-4-8-16-24;;/h3-
    20H,1-2H3;2*1H/q+2;;/p-2/b30-29+;;
  • Molecular Formula: C28H24Br2N6
  • Molecular Structure:CAS No:49564-56-9 (E)-bis(3-methyl-2-phenylimidazo[1,<br />2-a]pyridin-4-ium-1-yl)diazene

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49564-56-9 FAZADINIUM BROMIDE

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References of (E)-bis(3-methyl-2-phenylimidazo[1,
2-a]pyridin-4-ium-1-yl)diazene
Title: Fazadinium Bromide
CAS Registry Number: 49564-56-9
CAS Name: 1,1￠-Azobis[3-methyl-2-phenylimidazo[1,2-a]pyridinium] dibromide
Manufacturers' Codes: AH-8165
Trademarks: Fazadon (Glaxo Wellcome)
Molecular Formula: C28H24Br2N6
Molecular Weight: 604.34
Percent Composition: C 55.65%, H 4.00%, Br 26.44%, N 13.91%
Literature References: A short-acting curarimimetic with rapid onset. Prepn: D. Jack, E. E. Glover, DE 2127355; eidem, US 3773746 (1971, 1973 both to Allen & Hanburys); E. E. Glover, M. Yorke, J. Chem. Soc. C 1971, 3280. Pharmacology: L. Bolger et al., Nature 238, 354 (1972); and toxicity data: P. Bellani et al., Farmaco Ed. Sci. 39, 846 (1984). Clinical pharmacokinetics: T. Busi et al., Minerva Anestesiol. 49, 485 (1983). Clinical use: G. Minutella, G. Bongiovanni, ibid. 301; A. Lusini et al., ibid. 393.
 
Derivative Type: Dihydrate
Properties: Yellow crystals from water, mp 215-219° (softens at 196°). Also reported as yellow solid from methanol/ethyl acetate, mp 218-220°. uv max (H2O): 285, 297 nm (log e 4.04, 4.34). LD50 i.v. in rats: 1.5 mM/kg (Bellani).
Melting point: mp 215-219° (softens at 196°); mp 218-220°
Absorption maximum: uv max (H2O): 285, 297 nm (log e 4.04, 4.34)
Toxicity data: LD50 i.v. in rats: 1.5 mM/kg (Bellani)
 
Therap-Cat: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents.