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CAS No 495-99-8 , bis(8-hydroxyquinolinium) sulphate

  • Name: bis(8-hydroxyquinolinium) sulphate
  • Synonyms: Hydroxystilbamidine;bis(8-hydroxyquinolinium) sulphate;
  • CAS Registry Number:
  • Flash Point: 262.044°C
  • Boiling Point: 509.678°C at 760 mmHg
  • Density: 1.288g/cm3
  • Refractive index: 1.654
  • Flash Point: 262.044°C
  • EINECS: 207-811-0
  • Molecular Weight: 280.3244
  • InChI: InChI=1S/C16H16N4O/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21/h1-9,21H,(H3,17,18)(H3,19,20)/b4-1+
  • Molecular Formula: C16H16N4O
  • Molecular Structure:CAS No:495-99-8 bis(8-hydroxyquinolinium) sulphate

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References of bis(8-hydroxyquinolinium) sulphate
Title: Hydroxystilbamidine
CAS Registry Number: 495-99-8
CAS Name: 4-[2-[4-(Aminoiminomethyl)phenyl]ethenyl]-3-hydroxybenzenecarboximidamide
Synonyms: 2-hydroxy-4,4￠-stilbenedicarboxamidine; 2-hydroxy-4,4￠-diamidinostilbene; 2-hydroxy-4,4￠-diguanylstilbene; 2-hydroxystilbamide
Molecular Formula: C16H16N4O
Molecular Weight: 280.32
Percent Composition: C 68.55%, H 5.75%, N 19.99%, O 5.71%
Literature References: Prepn: J. N. Ashley, J. O. Harris, J. Chem. Soc. 1946, 567; A. J. Ewins et al., GB 574486; A. J. Ewins, US 2510047 (1946, 1950 both to May & Baker). Organ and tissue distribution in animals: I. Snapper et al., Cancer 4, 1246 (1951). Pharmacology and antiprotozoal activity: I. Snapper et al., Trans. N.Y. Acad. Sci. 14, 269 (1952). Probe for studying nucleic acid conformation: B. Festy, C.R. Seances Acad. Sci. Ser. D 266, 1433 (1968); B. Festy, M. Daune, Biochemistry 12, 4827 (1973); B. Festy et al., Biochim. Biophys. Acta 407, 24 (1975). Crystal structure: C. Courseille et al., C.R. Seances Acad. Sci. Ser. C 274, 1921 (1972). Use as a fluorochrome for selective staining of nuclei: L. B. Murgatroyd, Histochemistry 74, 107 (1982). Review: B. Festy in Antibiotics vol. 5, pt. 2, F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 223-235.
Properties: Yellow microcrystals from nitrobenzene, mp 235°. LD50 in mice (mg/g); 0.027 i.v.; 0.14 s.c. (Ewins, 1950).
Melting point: mp 235°
Toxicity data: LD50 in mice (mg/g); 0.027 i.v.; 0.14 s.c. (Ewins, 1950)
 
Derivative Type: Isethionate
CAS Registry Number: 533-22-2
Molecular Formula: C20H28N4O9S2
Molecular Weight: 532.59
Percent Composition: C 45.10%, H 5.30%, N 10.52%, O 27.04%, S 12.04%
Properties: Yellow crystals, discolored by light, mp 286° (dec). Freely sol in water. Soly in alcohol ~1.0 g/100 ml. Practically insol in ether. pH of a 1% aq soln 3.3 to 5.3. Solns show strong yellow fluorescence under uv light. Solns should be freshly prepared. Although the hydroxy compd is more stable in soln, such solns should not be stored and must not be used if cloudy.
Melting point: mp 286° (dec)
 
Therap-Cat: Antiprotozoal (Leishmania).
Keywords: Antiprotozoal (Leishmania).