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CAS No 494-03-1 , N,N-bis(2-chloroethyl)naphthalen-2-amine

  • Name: N,N-bis(2-chloroethyl)naphthalen-2-amine
  • Synonyms: Chlornaphthin; Chloronaftina; Aleukon; Nafticlorina; Cloronaftina; Chloronaphthina;Chlornaphazine; Chlornaftina; Chloronaphthine;N,N-bis(2-chloroethyl)naphthalen-2-amine;
  • CAS Registry Number:
  • Flash Point: 204.4°C
  • Boiling Point: 414.3°C at 760 mmHg
  • Density: 1.234g/cm3
  • Refractive index: 1.63
  • Safety Statements: Confirmed human carcinogen producing bladder tumors. Human and experimental carcinogenic data. Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Flash Point: 204.4°C
  • EINECS: 207-785-0
  • Molecular Weight: 268.1816
  • InchiKey: XCDXSSFOJZZGQC-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H15Cl2N/c15-7-9-17(10-8-16)14-6-5-12-3-1-2-4-13(12)11-14/h1-
    6,11H,7-10H2
  • Molecular Formula: C14H15Cl2N
  • Molecular Structure:CAS No:494-03-1 N,N-bis(2-chloroethyl)naphthalen-2-amine

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References of N,N-bis(2-chloroethyl)naphthalen-2-amine
Title: Chlornaphazine
CAS Registry Number: 494-03-1
CAS Name: N,N-Bis(2-chloroethyl)-2-naphthylamine
Synonyms: dichloroethyl-b-naphthylamine; b-naphthyldi(2-chloroethyl)amine; b-naphthylbis(b-chloroethyl)amine; di(2-chloroethyl)-b-naphthylamine
Manufacturers' Codes: CB-1048; R-48
Trademarks: Cloronaftina; Erysan
Molecular Formula: C14H15Cl2N
Molecular Weight: 268.18
Percent Composition: C 62.70%, H 5.64%, Cl 26.44%, N 5.22%
Literature References: Prepd from 2-C10H7N(C2H4OH)2 by treatment with POCl3: Ross, J. Chem. Soc. 1949, 183; Ghielmetti, Farmaco Ed. Sci. 5, 275 (1950); 11, 603 (1956). Mechanism of action studies: Jeney et al., Kiserl. Orvostud. 20, 369 (1968), C.A. 70, 18766j (1969). Review of carcinogenicity studies: IARC Monographs 4, 119-124 (1974).
Properties: Platelets from petr ether, mp 54-56°. bp5 210°. Very sparingly sol in water, glycerol. More sol (in ascending degree) in petr ether, ethanol, olive oil, ether, acetone, benzene.
Melting point: mp 54-56°
Boiling point: bp5 210°
CAUTION: This substance has been listed as a known carcinogen: Fourth Annual Report on Carcinogens (NTP 85-002, 1985) p 44; delisted because no U.S. residents exposed: Fifth Annual Report on Carcinogens (NTP 89-239, 1989) p 340.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards.