Title: Epimedii Herba
Synonyms: Yinyanghuo
Literature References: Chinese herbal medicine made from the dried aerial parts of
Epimedium sp. (
Berberidaceae). Used as a tonic and in the treatment of rheumatic disease and hypertension. Principal constituents are prenylflavone glycosides such as icariin, epimedosides, sagittatosides, and baohuosides. Isoln of icariin from
E. macranthum: S. Akai,
J. Pharm. Soc. Jpn. 55, 537 (1935),
C.A. 29, 5850 (1935). Revised structure: Y. Tokuoka
et al., Yakugaku Zasshi 95, 825 (1975),
C.A. 83, 111172r (1975). HPLC determn of constituents: M. Mizuno
et al., Chem. Pharm. Bull. 36, 3487 (1988); Y. Ito
et al., J. Chromatogr. 456, 392 (1988). Immunoregulatory effects of icariin
in vitro: W. He
et al., Arzneim.-Forsch. 45, 910 (1995). Review: W. Tang, G. Eisenbrand in
Chinese Drugs of Plant Origin (Springer-Verlag, Berlin, 1992) pp 491-498.
Derivative Type: Icariin
CAS Registry Number: 489-32-7
CAS Name: 3-[(6-Deoxy-a-L-mannopyranosyl
)oxy]-7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4
H-1-benzopyran-4-one
Synonyms: 4￠-
O-methyl-8-g,g-dimethylallylkaempferol-3-rhamnoside-7-glucoside
Molecular Formula: C33H40O15
Molecular Weight: 676.66
Percent Composition: C 58.57%, H 5.96%, O 35.47%
Properties: Sesquihydrate, mp 231.5°. [a]D15 -87.09° (in pyridine). Sol in pyridine. Insol in water, alcohol, chloroform, acetone, methanol, ethyl acetate.
Melting point: mp 231.5°
Optical Rotation: [a]D15 -87.09° (in pyridine)
