Home > Name List By other > (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4, 5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one

CAS No 485-49-4 , (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,
5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one

  • Name: (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,
    5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
  • Synonyms: CHEBI:3092; 485-49-4; NSC 32192; NSC32192; Bicculine;(+)-Bicuculline;(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,
    5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one; Bicuculline (+); d-Bicuculline; Bicucullin;
  • CAS Registry Number:
  • Transport: UN 1544 6
  • Melting Point: 196-198 ºC
  • Density: 1.473 g/cm3
  • Safety Statements: A poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.
  • Hazard Symbols: T: Toxic;N: Dangerous for the environment;
  • EINECS: 207-619-7
  • Molecular Weight: 367.35208
  • InchiKey: IYGYMKDQCDOMRE-ZWKOTPCHSA-N
  • InChI: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-
    2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,
    1H3/t17-,18+/m0/s1
  • Risk Statements: 23/24/25-50
  • Molecular Formula: C20H17NO6
  • Molecular Structure:CAS No:485-49-4 (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,<br />5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one

Related products

Search by region :

Select to

485-49-4 Furo[3,4-e]-1,3-benzodioxol-8(6H)-one,6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-

  • China Haiqiang Chemicals Co., Ltd [Manufacturers]
  • Tel: +86-571-86465881
  • Fax: +86-571-86414728
  • Address: No.407 Tianyuange, No.218 Daomao Xiang, Hangzhou City, Zhejiang Province, China. Hangzhou,ZhejiangChina
Contact Supplier

485-49-4 (+)-Bicuculline

Contact Supplier

485-49-4 Furo[3,4-e]-1,3-benzodioxol-8(6H)-one,6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-

  • United States AvaChem Scientific LLC [Manufacturers]
  • Tel: 210 667 3815
  • Address: P. O. Box 780442 San Antonio, TX 78278 U.S.A. null,nullUnited States
Contact Supplier

485-49-4 Acetamide,N-[2-(aminosulfonyl)-5,6-dihydro-6-methyl-7,7-dioxido-4H-thieno-[2,3-b]thiopyran-4-yl]-, (4S-trans)

  • China Chemvon Biotechnology Co., Ltd. null
  • Fax: +86-21-50790419
  • Address: Suite B-10#, 6999 Chuansha Road,Pudong District, Shanghai 201202, China null,nullChina
Contact Supplier

485-49-4 (+)-BICUCULLINE

  • China Rongkang industry Co.,Ltd [Manufacturer]
  • Tel: +86-571-8801 0713
  • Fax: +86-571-8801 0679
  • Address: Rongkang Industry Co.,Ltd
    2-3-1502 XIANGXIELI GARDEN
    NO.4 STREET XIASHA
    HANGZHOU, CHINA P.C:310018 null,nullChina
Contact Supplier

485-49-4 (+)-Bicuculline

  • China Yingxuan Chempharm Co.,LTD [Manufacturer]
  • Tel: 86-21-60875125
  • Address: No.2588,Jinhai Rd.pudong,Shanghai,China Shanghai ,nullChina
Contact Supplier

485-49-4 (+)-BICUCULLINE

  • China Leap Labchem Co.,Ltd [Manufacturer]
  • Tel: +86-571-87756549
  • Fax: +86-571-87755464
  • Address: Leap Labchem Co.,Ltd
    Zhongtian Mansion,No.173,
    Yugu Road Xihu District,
    Hangzhou,310007,PR,China null,nullChina
Contact Supplier

485-49-4 Furo[3,4-e]-1,3-benzodioxol-8(6H)-one,6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-

Contact Supplier

485-49-4 (+)-BICUCULLINE

  • China Pharmasi Chemicals Co.Ltd [Manufacturer]
  • Tel: +86-21-67752521
  • Fax: +86-21-57819315
  • Address: Pharmasi Chemicals Co.Ltd
    Address: Room 903,
    JIAHE business building,
    songjiang,shanghai,china null,nullChina
Contact Supplier

485-49-4 Furo[3,4-e]-1,3-benzodioxol-8(6H)-one,6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-

  • China Yingxuan Chempharm Co.,Ltd [Manufacturers]
  • Tel: +86-21-60875125
  • Fax: +86-21-60875126
  • Address: No 2588,Jinhai Road,Pudong,Shanghai,China Shanghai,ShanghaiChina
Contact Supplier

Select to

4/6
Previous 1 2 3 4 5 6 Next
References of (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,
5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
Title: Bicuculline
CAS Registry Number: 485-49-4
CAS Name: (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
Molecular Formula: C20H17NO6
Molecular Weight: 367.35
Percent Composition: C 65.39%, H 4.66%, N 3.81%, O 26.13%
Literature References: Alkaloid naturally occurring in the d-form; found in Dicentra cucullaria (L.) Bernh., Adlumia fungosa (Ait.) Greene, Fumariaceae, and several Corydalis species: Manske, Can. J. Res. 7, 265 (1932); 8, 210, 407 (1933); 9, 436 (1933); Edwards, Handa, Can. J. Chem. 39, 1801 (1961). Synthesis of dl-form: Groenewoud, Robinson, J. Chem. Soc. 1936, 199. Resolution of isomers: Haworth et al., Nature 165, 529 (1950). Stereoisomer of adlumidine, q.v., and of capnoidine: Manske, J. Am. Chem. Soc. 72, 3207 (1950). Preliminary stereochemical studies: Safe, Moir, Can. J. Chem. 42, 160 (1964). Revised stereochemistry: Blaha et al., Collect. Czech. Chem. Commun. 29, 2328 (1964); Snatzke et al., Tetrahedron 25, 5059 (1969). Crystal and molecular structure: Gorinsky, Moss, J. Cryst. Mol. Struct. 3, 299 (1973). Shows GABA (q.v.) antagonist activity: Curtis et al., Nature 226, 1222 (1970).
Properties: Elongated plates from chloroform-methanol, mp 215°; also reported as mp 177°, solidifies and remelts 193-195°: Manske, Can. J. Res. 21B, 13 (1943). uv max (acidified ethanol): 225, 296, 324 nm (e 36700, 6390, 5870). [a]D25 +130.5° (CHCl3). pKa 4.84. Sol in benzene, chloroform, ethyl acetate. Sparingly sol in alc and ether.
Melting point: mp 215°; mp 177°
pKa: pKa 4.84
Optical Rotation: [a]D25 +130.5° (CHCl3)
Absorption maximum: uv max (acidified ethanol): 225, 296, 324 nm (e 36700, 6390, 5870)