Title: Osthole
CAS Registry Number: 484-12-8
CAS Name: 7-Methoxy-8-(3-methyl-2-butenyl)-2
H-1-benzopyran-2-one
Synonyms: 7-methoxy-8-(3-methyl-2-butenyl)coumarin; 8-(3-methyl-2-butenyl)herniarin
Molecular Formula: C15H16O3
Molecular Weight: 244.29
Percent Composition: C 73.75%, H 6.60%, O 19.65%
Literature References: From rhizome of
Peucedanum ostruthium (L.) Koch
(Imperatoria ostruthium L.
) Umbelliferae: Herzog, Krohn,
Arch. Pharm. 247, 553 (1909); Butenandt, Marten,
Ann. 495, 187 (1932); from
Prangos pabularia Lindl.,
Umbelliferae: Pigulevskii, Kuznetsova,
Dokl. Akad. Nauk SSSR 61, 309 (1948),
C.A. 43, 3416d (1949); from
Flindersia bennettiana F. Muell.,
Rutaceae: Galbraith
et al., Aust. J. Chem. 13, 427 (1960). Structure: Sp?th, Pesta,
Ber. 66, 754 (1933). Synthesis: Sp?th, Holzen,
ibid. 67, 264 (1934); Murayama
et al., Chem. Pharm. Bull. 20, 741 (1972).
Properties: Prisms from ether. mp 83-84°. uv max: 322, 258 nm (e 8000, 4300). Practically insol in water; sol in aq alkalies, alcohol, chloroform, acetone, boiling petr ether.
Melting point: mp 83-84°
Absorption maximum: uv max: 322, 258 nm (e 8000, 4300)