CAS No 47739-98-0 , Clocapramine

Name: Clocapramine
Synonyms: Clocapramine;Clocapraminum;28058-62-0 (Di-hydrochloride);Clocapramina [inn-spanish];Clocapramina;3-chlorocarpipramine;1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide;65016-29-7 (Di-hydrochloride monohydrate);1-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-4-piperidino-4-piperidinecarboxamide;
CAS Registry Number:47739-98-0
Flash Point: 354.2°C
Boiling Point: 662.1°C at 760 mmHg
Density: 1.195g/cm³
Refractive index: 1.602
Flash Point: 354.2°C
EINECS: 209-103-7
Molecular Weight: 0
InChI: InChI=1S/C28H37ClN4O/c29-24-12-11-23-10-9-22-7-2-3-8-25(22)33(26(23)21-24)18-6-15-31-19-13-28(14-20-31,27(30)34)32-16-4-1-5-17-32/h2-3,7-8,11-12,21H,1,4-6,9-10,13-20H2,(H2,30,34)
Molecular Formula: C₂₈H₃₇ClN₄O
Molecular Structure:

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           47739-98-0 Clocapramine
           Clocapramine, Min 99%
 
             Finechemie Co., Ltd. 
             
              [Manufacturer]
Tel: +86-23-99186710 
Fax: +86-23-99186729 
Address: 28th Floor Mordern Building,New-Tech Zone400020  ChongqingCHINA Chongqing,nullChina

           47739-98-0 Clocapramine
           Clocapramine, 99%
 
             Facus Pharmaceutical Co., Ltd. 
             
              [Manufacturer]
Tel: +86-(0)574-62378411   
Fax: +86-(0)574-62378410  
Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 
 
315800  NingboCHINA Ningbo,nullChina

           47739-98-0 CLOCAPRAMINE
           
             Nanjing Chemlin Chemical Industry Co.,Ltd.
             
              [Manufacturer]
Tel:  +86 25 8369-7070/ +86 138 51816776 (Mobile)
Fax:  +86 25 8345-3275
Address: Rm.902 Longyin Plaza,
No. 217 Zhongshan Rd.
(N)Nanjing 210009,China null,nullChina

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References of Clocapramine

Title: Clocapramine
CAS Registry Number: 47739-98-0
CAS Name: 1￠-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4￠-bipiperidine]-4￠-carboxamide
Synonyms: 3-chloro-5-[3-(4-piperidino-4-carbamoylpiperidino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 3-chlorocarpipramine; clocarpramine; CCP
Molecular Formula: C28H37ClN4O
Molecular Weight: 481.07
Percent Composition: C 69.91%, H 7.75%, Cl 7.37%, N 11.65%, O 3.33%
Literature References: Prepn: M. Nakanishi, C. Tashiro, DE 1905765; eidem, US 3668210 (1969, 1972, both to Yoshitomi); M. Nakanishi et al., J. Med. Chem. 13, 644 (1970). Pharmacology and toxicity: M. Nakanishi et al., Arzneim.-Forsch. 21, 391 (1971). Effect on metabolism of serotonin and catecholamines: M. Nakanishi, M. Setoguchi, ibid. 23, 806 (1973). Metabolism: M. Nakanishi et al., J. Pharm. Soc. Jpn. 91, 1042 (1971). HPLC determn in plasma: K. Hikida et al., Anal. Sci. 6, 367 (1990). Review: Jpn. Med. Gaz. 10(7), 5 (1973).

Derivative Type: Dihydrochloride monohydrate
CAS Registry Number: 60789-62-0
Manufacturers' Codes: Y-4153
Trademarks: Clofekton (Yoshitomi)
Molecular Formula: C28H37ClN4O.2HCl.H2O
Molecular Weight: 572.01
Percent Composition: C 58.79%, H 7.22%, Cl 18.59%, N 9.79%, O 5.59%
Properties: White, bitter tasting, crystalline powder, mp 267°. Soly in water: <3.5 g/100 ml. Freely sol in glacial acetic acid. Practically insol in ether, acetone. LD50 in mice, rats (mg/kg): 160, 125 i.p.; 2550, 6800 orally (Nakanishi).
Melting point: mp 267°
Toxicity data: LD50 in mice, rats (mg/kg): 160, 125 i.p.; 2550, 6800 orally (Nakanishi)

Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics.