Home > Name List By a > Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

CAS No 477-27-0 , Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

  • Name: Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
  • Synonyms: NSC33411; O10-Demethylcolchicine; Benzo[a]heptalene, acetamide deriv.;Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-;Acetamide,N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-; Colchiceine (6CI,7CI,8CI);
  • CAS Registry Number:
  • Melting Point: 172-1740C
  • Flash Point: 396.2°C
  • Boiling Point: 731.5°Cat760mmHg
  • Density: 1.31g/cm3
  • Refractive index: 1.61
  • Safety Statements: A deadly human poison by ingestion. An experimental poison by intravenous, intraperitoneal and possibly other routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
  • Flash Point: 396.2°C
  • EINECS: 207-512-5
  • Molecular Weight: 385.45
  • InChI: InChI=1/C21H23NO6/c1-11(23)22-15-7-5-12-9-18(26-2)20(27-3)21(28-4)19(12)13-6-8-16(24)17(25)10-14(13)15/h6,8-10,15H,5,7H2,1-4H3,(H,22,23)(H,24,25)/t15-/m0/s1
  • Molecular Formula: C21H23 N O6
  • Molecular Structure:CAS No:477-27-0 Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

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477-27-0 COLCHICEINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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477-27-0 COLCHICEINE ( N-[(7S)-5,6,7,9-TETRAHYDRO-10-HYDROXY-1,2,3,-TRIMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL]ACETAMIDE )

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
Title: Colchiceine
CAS Registry Number: 477-27-0
CAS Name: N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
Synonyms: 7-acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
Molecular Formula: C21H23NO6
Molecular Weight: 385.41
Percent Composition: C 65.44%, H 6.02%, N 3.63%, O 24.91%
Literature References: Deriv of colchicine, q.v., isolated from Colchicum autumnale L., Liliaceae: Santavy, Macák, Collect. Czech. Chem. Commun. 19, 805 (1954). Toxicity data: B. Goldberg et al., Cancer 3, 124 (1950). Structure and synthesis: Nakamura, Chem. Pharm. Bull. 10, 299 (1962). Circular dichroism: J. Hrbek et al., Collect. Czech. Chem. Commun. 47, 2258 (1982). Effect on antibody response induced in vitro: J. Sterzl et al., Folia Microbiol. 27, 256 (1982).
Properties: Yellow crystals from dioxane + ether, mp 178-179°. [a]D25 -255.1° (c = 1 in chloroform). uv max (95% ethanol): 351, 244 nm (log e 4.28, 4.51). Slightly sol in water; freely sol in alcohol, chloroform. Almost insol in benzene, ether.
Melting point: mp 178-179°
Optical Rotation: [a]D25 -255.1° (c = 1 in chloroform)
Absorption maximum: uv max (95% ethanol): 351, 244 nm (log e 4.28, 4.51)
 
Derivative Type: Ethyl ether
Molecular Formula: C23H27NO6
Molecular Weight: 413.46
Percent Composition: C 66.81%, H 6.58%, N 3.39%, O 23.22%
Properties: Needles from ethyl acetate + ether, mp 135-139°. [a]D25 -129.4° (c = 1 in chloroform). uv max (95% ethanol): 351, 243.5 nm (log e 4.21, 4.45). LD50 i.p. in mice: 84 mg/kg (Goldberg).
Melting point: mp 135-139°
Optical Rotation: [a]D25 -129.4° (c = 1 in chloroform)
Absorption maximum: uv max (95% ethanol): 351, 243.5 nm (log e 4.21, 4.45)
Toxicity data: LD50 i.p. in mice: 84 mg/kg (Goldberg)