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CAS No 461-78-9 , 1-(4-chlorophenyl)-2-methylpropan-2-amine

  • Name: 1-(4-chlorophenyl)-2-methylpropan-2-amine
  • Synonyms: Clorfentermina;1-(4-chlorophenyl)-2-methylpropan-2-amine; Clorfentermina [INN-Spanish]; Chlorphenterminum [INN-Latin]; Chlorpentermine; Effox; Teramine; Chlorophentermine;Desopimon;
  • CAS Registry Number:
  • Flash Point: 127°C
  • Boiling Point: 255.8°Cat760mmHg
  • Density: 1.074g/cm3
  • Refractive index: 1.537
  • Safety Statements: Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: blood pressure elevation and sympathetic nervous system stimulation. An experimental teratogen. Mutation data reported. An anorectic drug which diminishes the appetite. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • HS Code: 29222900
  • Flash Point: 127°C
  • EINECS: 207-314-9
  • Molecular Weight: 183.67786
  • InchiKey: ZCKAMNXUHHNZLN-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3
  • Molecular Formula: C10H14ClN
  • Molecular Structure:CAS No:461-78-9 1-(4-chlorophenyl)-2-methylpropan-2-amine

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References of 1-(4-chlorophenyl)-2-methylpropan-2-amine
Title: Chlorphentermine
CAS Registry Number: 461-78-9
CAS Name: 4-Chloro-a,a-dimethylbenzeneethanamine
Synonyms: 4-chloro-a,a-dimethylphenethylamine; a,a-dimethyl-p-chlorophenethylamine; 1-(p-chlorophenyl)-2-methyl-2-propylamine; 1-(p-chlorophenyl)-2-methyl-2-aminopropane; clorfentermina
Trademarks: Lucofen (Lundbeck); Teramine (Darby)
Molecular Formula: C10H14ClN
Molecular Weight: 183.68
Percent Composition: C 65.39%, H 7.68%, Cl 19.30%, N 7.63%
Literature References: Prepn: Bachman et al., J. Am. Chem. Soc. 76, 3972 (1954); Ferrari, Farmaco Ed. Sci. 15, 337 (1960); FR M1299 and FR 1296132 (1962 to Simes), C.A. 58, 4467e, 3352g (1963); GB 90633l (1962 to Kefalas), C.A. 58, 6654c (1963). Pharmacology: Jun et al., Can. J. Pharm. Sci. 4, 27 (1969); Ciborska et al., Acta Pol. Pharm. 26, 595 (1969); Moeller-Nielsen, Dubnick, Proc. Int. Symp. Amphetamines Relat. Compounds 1969, E. Costa, Ed. (Raven Press, New York, 1970) pp 63-73.
Properties: Liquid. bp2 100-102°.
Boiling point: bp2 100-102°
 
Derivative Type: Hydrochloride
CAS Registry Number: 151-06-4
Trademarks: Pre-Sate (Warner-Lambert)
Molecular Formula: C10H14ClN.HCl
Molecular Weight: 220.14
Percent Composition: C 54.56%, H 6.87%, Cl 32.21%, N 6.36%
Properties: Crystals from alcohol + ether, mp 234°. Soly in water: >20%. pH of 1% aq soln ~5.5. LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska).
Melting point: mp 234°
Toxicity data: LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska)
 
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.13.
Therap-Cat: Anorexic.
Keywords: Anorexic; CNS Stimulant.