Title: Bostrycoidin
CAS Registry Number: 4589-33-7
CAS Name: 6,9-Dihydroxy-7-methoxy-3-methylbenz[
g]isoquinoline-5,10-dione
Synonyms: 5,8-dihydroxy-6-methoxy-3-methyl-2-aza-9,10-anthraquinone
Molecular Formula: C15H11NO5
Molecular Weight: 285.25
Percent Composition: C 63.16%, H 3.89%, N 4.91%, O 28.04%
Literature References: Antibiotic substance produced by
Fusarium bostrycoides: Hamilton
et al., Antibiot. Chemother. 3, 853 (1953); Cajori
et al., J. Biol. Chem. 208, 107 (1954). Structure: Arsenault,
Tetrahedron Lett. 1965, 4033. Synthesis: D. W. Cameron
et al., ibid. 21, 5089 (1980).
Properties: Dark red crystals; mp 243-244°, changes to purple in alkaline medium, yellow in acid medium. Stable at room temp and withstands autoclaving. Insol in water; sol in abs ethanol and in 60% ethanol; moderately sol in dioxane, benzene, acetone, chloroform, carbon tetrachloride. Soluble in aq sodium carbonate solns. Partly sol in corn oil. Active
in vitro against
Mycobacterium tuberculosis. Serum seems to interfere.
Melting point: mp 243-244°