CAS No 4498-32-2 , 5-[2-(dimethylamino)ethyl]-11-methylbenzo[b][1,4]benzodiazepin-6-one

Name: 5-[2-(dimethylamino)ethyl]-11-methylbenzo[b][1,4]benzodiazepin-6-one
Synonyms: Dibenzepinum [INN-Latin];Dibenzepine; Dibenzepina [INN-Spanish]; Noveril;5-[2-(dimethylamino)ethyl]-11-methylbenzo[b][1,4]benzodiazepin-6-one; Dibenzepine [INN-French]; Dibenzepin [INN:BAN]; 4498-32-2;
CAS Registry Number:4498-32-2
Transport: 3249
Flash Point: 194.9°C
Boiling Point: 451.7°Cat760mmHg
Density: 1.134g/cm³
Refractive index: 1.592
Safety Statements: Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Many dibenz-azepine compounds have central nervous system effects. When heated to decomposition it emits toxic fumes of NO_x. See also DIAZEPAM.
Flash Point: 194.9°C
Molecular Weight: 295.37884
InchiKey: QPGGEKPRGVJKQB-UHFFFAOYSA-N
InChI: InChI=1S/C18H21N3O/c1-19(2)12-13-21-17-11-7-6-10-16(17)20(3)15-9-5-4-8-
14(15)18(21)22/h4-11H,12-13H2,1-3H3
Molecular Formula: C₁₈H₂₁N₃O
Molecular Structure:

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References of 5-[2-(dimethylamino)ethyl]-11-methylbenzo[b][1,4]benzodiazepin-6-one

Title: Dibenzepin
CAS Registry Number: 4498-32-2
CAS Name: 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one
Synonyms: 5-methyl-10b-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine
Manufacturers' Codes: HF-1927
Molecular Formula: C18H21N3O
Molecular Weight: 295.38
Percent Composition: C 73.19%, H 7.17%, N 14.23%, O 5.42%
Literature References: Prepn: F. Hunziker et al., Arzneim.-Forsch. 13, 324 (1963); GB 961106; J. Schmutz, F. Hunziker, US 3312689 and US 3419547 (1964, 1967, 1968 all to Wander). Metabolism: H. Lehner et al., Arzneim.-Forsch. 17, 185 (1967). Comprehensive description: A. Egli, W. R. Michaelis, Anal. Profiles Drug Subs. 9, 181-206 (1980).
Properties: mp 116-117°. bp0.01 185°.
Melting point: mp 116-117°
Boiling point: bp0.01 185°

Derivative Type: Hydrochloride
CAS Registry Number: 315-80-0
Trademarks: Neodalit (HÝsle); Noveril (Morishita)
Molecular Formula: C18H21N3O.HCl
Molecular Weight: 331.84
Percent Composition: C 65.15%, H 6.68%, N 12.66%, O 4.82%, Cl 10.68%
Properties: Crystals, mp 238°. uv max (0.1N HCl): 204, 220 nm (log e 4.530, 4.458). pKa 8.25. Sol in water, alcohol, chloroform. LD50 orally in mice: 215 mg/kg (Hunziker).
Melting point: mp 238°
pKa: pKa 8.25
Absorption maximum: uv max (0.1N HCl): 204, 220 nm (log e 4.530, 4.458)
Toxicity data: LD50 orally in mice: 215 mg/kg (Hunziker)

Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.