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CAS No 42924-53-8 , 4-(6-methoxynaphthalen-2-yl)butan-2-one Search by region : Germany

  • Name: 4-(6-methoxynaphthalen-2-yl)butan-2-one
  • Synonyms: Listran; Consolan; Mebutan; Relif; Nabumetona; Arthaxan; Relifen;Relafen; Relifex;4-(6-methoxynaphthalen-2-yl)butan-2-one;
  • CAS Registry Number:
  • Melting Point: 80-810C
  • Density: 1.084 g/cm3
  • Refractive index: 1.572
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: Xn
  • Molecular Weight: 228.28634
  • InchiKey: BLXXJMDCKKHMKV-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-
    10H,3-4H2,1-2H3
  • Risk Statements: 22-40
  • Molecular Formula: C15H16O2
  • Molecular Structure:CAS No:42924-53-8 4-(6-methoxynaphthalen-2-yl)butan-2-one

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42924-53-8 Nabumetone

  • Nabumetone
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  • Address: CHEMOS GmbH
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References of 4-(6-methoxynaphthalen-2-yl)butan-2-one
Title: Nabumetone
CAS Registry Number: 42924-53-8
CAS Name: 4-(6-Methoxy-2-naphthalenyl)-2-butanone
Synonyms: 4-(6-methoxy-2-naphthyl)-butan-2-one
Manufacturers' Codes: BRL-14777
Trademarks: Arthaxan (GSK); Balmox (GSK); Consolan (Novo); Nabuser (Geymonat); Relafen (GSK); Relifen (GSK); Relifex (GSK)
Molecular Formula: C15H16O2
Molecular Weight: 228.29
Percent Composition: C 78.92%, H 7.06%, O 14.02%
Literature References: Nonacidic, lipophillic prodrug; metabolized in vivo to 6-methoxy-2-naphthylacetic acid which inhibits prostaglandin synthesis. Prepn: A. W. Lake, C. J. Rose, DE 2442305; eidem, US 4061779 (1975, 1977 both to Beecham); A. C. Goudie et al., J. Med. Chem. 21, 1260 (1978). Pharmacology: E. A. Boyle et al., J. Pharm. Pharmacol. 34, 562 (1982); B. Nunn, P. D. Chamberlain, ibid. 576. Metabolism: R. E. Haddock et al., Xenobiotica 14, 327 (1984). HPLC determn in plasma: J. E. Ray, R. O. Day, J. Chromatogr. 336, 234 (1984). Symposia on pharmacology, pharmacokinetics and clinical efficacy: Int. Congr. Symp. Ser. - R. Soc. Med. 69, 1-215 (1985); J. Rheumatol. 19, Suppl. 36, 1-91 (1992). Review: S. L. Dahl, Ann. Pharmacother. 27, 456-463 (1993).
Properties: Crystals from ethanol, mp 80°.
Melting point: mp 80°
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Anti-inflammatory (Nonsteroidal).