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CAS No 426-13-1 , Fluoromethalone Search by region : China

  • Name: Fluoromethalone
  • Synonyms: 9-alpha-fluoro-11-beta,17-alpha-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione; 11b,17a-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione;9a-Fluoro-11b,17a-dihydroxy-6a-methyl-1,4-pregnadiene-3,20-dione;98%;Fluoromethalone;
  • CAS Registry Number:
  • Melting Point: 292 - 303
  • Flash Point: 272.6°C
  • Boiling Point: 527.1°Cat760mmHg
  • Density: 1.25g/cm3
  • Refractive index: 55 ° (C=1, Pyridine)
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 272.6°C
  • EINECS: 207-041-5
  • Molecular Weight: 376.47
  • InChI: InChI=1/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
  • Risk Statements: S36
  • Molecular Formula: C22H29FO4
  • Molecular Structure:CAS No:426-13-1 Fluoromethalone

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References of Fluoromethalone
Title: Fluorometholone
CAS Registry Number: 426-13-1
CAS Name: (6a,11b)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
Synonyms: 21-desoxy-9a-fluoro-6a-methylprednisolone; 21-desoxy-6a-methyl-9a-fluoroprednisolone; fluormetholon
Trademarks: Delmeson (Aventis); Efflumidex (Allergan); Fluaton (Tubi Lux); Flumetholon (Santen); Fluor-Op (Novartis); FML (Allergan)
Molecular Formula: C22H29FO4
Molecular Weight: 376.46
Percent Composition: C 70.19%, H 7.76%, F 5.05%, O 17.00%
Literature References: Prepn: F. H. Lincoln et al., US 2867637 (1959 to Upjohn). Prepn of acetate and other esters: B. J. Magerlein et al., US 3038914 (1962 to Upjohn). Pharmacology of acetate: A. Kupferman et al., Arch. Ophthalmol. 100, 640 (1982). HPLC determn: H. Tokunaga et al., Chem. Pharm. Bull. 32, 4012 (1984). Clinical evaluation in ocular inflammation: H. M. Leibowitz et al., Ann. Ophthalmol. 16, 1110 (1984).
Properties: Crystals from acetone, mp 292-303°.
Melting point: mp 292-303°
 
Derivative Type: 17-Acetate
CAS Registry Number: 3801-06-7
Trademarks: Eflone (Novartis)
Molecular Formula: C24H31FO5
Molecular Weight: 418.50
Percent Composition: C 68.88%, H 7.47%, F 4.54%, O 19.12%
Properties: Crystals from ethyl acetate + hexanes, mp 230-232°. [a]D +28° (chloroform).
Melting point: mp 230-232°
Optical Rotation: [a]D +28° (chloroform)
 
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.