Home > Name List By p > Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-

CAS No 41767-29-7 , Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-

  • Name: Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-
  • Synonyms: Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-;Butyl 6a-fluoro-11b-hydroxy-3,20-dioxo-16a-methyl-1,4-pregnadien-21-oate; Fluocortin butyl ester;Butyl 6a-fluoro-11b-hydroxy-16a-methyl-3,20-dioxopregna-1,4-dien-21-oate; Vaspit;Butyl6a-fluoro-11b-hydroxy-16a-methyl-3,20-dioxopregna-1,4-dien-21-oate;Fluocortin butyl; Varlane; SH K 203;
  • CAS Registry Number:
  • Flash Point: 298°C
  • Boiling Point: 569.1°Cat760mmHg
  • Density: 1.2g/cm3
  • Refractive index: 1.547
  • Flash Point: 298°C
  • EINECS: 255-543-8
  • Molecular Weight: 446.5515032
  • InChI: InChI=1/C26H35FO5/c1-5-6-9-32-24(31)23(30)21-14(2)10-17-16-12-19(27)18-11-15(28)7-8-25(18,3)22(16)20(29)13-26(17,21)4/h7-8,11,14,16-17,19-22,29H,5-6,9-10,12-13H2,1-4H3/t14-,16+,17+,19+,20+,21-,22-,25+,26+/m1/s1
  • Molecular Formula: C26H35 F O5
  • Molecular Structure:CAS No:41767-29-7 Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-

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41767-29-7 Fluocortin Butyl

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41767-29-7 Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-

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41767-29-7 FLUOCORTIN BUTYL

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References of Pregna-1,4-dien-21-oicacid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6a,11b,16a)-
Title: Fluocortin Butyl
CAS Registry Number: 41767-29-7
CAS Name: (6a,11b,16a)-6-Fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-oic acid butyl ester
Synonyms: butyl 6a-fluoro-11b-hydroxy-16a-methyl-3,20-dioxopregna-1,4-dien-21-oate
Manufacturers' Codes: SH K 203
Trademarks: Varlane (Schering AG); Vaspit (Schering AG)
Molecular Formula: C26H35FO5
Molecular Weight: 446.55
Percent Composition: C 69.93%, H 7.90%, F 4.25%, O 17.91%
Literature References: The butyl ester deriv of fluocortolone-21-acid, a metabolite of fluocortolone, q.v., in humans. Prepn: H. Laurent et al., DE 2150268, DE 2150270; eidem, US 3824260 (1973, 1973, 1974, all to Schering AG); H. Laurent et al., Angew. Chem. 87, 70 (1975). Description of this new corticoid structure type, the pregnan-21-oic esters, their activity and methods for synthesis: H. Laurent et al., J. Steroid Biochem. 6, 185 (1975). Toxicity data: P. Günzel et al., Arzneim.-Forsch. 27, 2217 (1977). Series of articles on synthesis, pharmacology and clinical trials: ibid. 2185-2246.
Properties: Crystals from acetone/hexane, mp 195.1°. [a]D25 +136° (c = 0.5 in chloroform). uv max (methanol): 242 nm (e 16800). Soluble in chloroform, ethanol; poorly sol in ethyl ether. Insol in water. LD50 in mice, rats (g/kg): >4 orally and s.c. (Günzel).
Melting point: mp 195.1°
Optical Rotation: [a]D25 +136° (c = 0.5 in chloroform)
Absorption maximum: uv max (methanol): 242 nm (e 16800)
Toxicity data: LD50 in mice, rats (g/kg): >4 orally and s.c. (Günzel)
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.