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CAS No 41575-94-4 , Carboplatin

  • Name: Carboplatin
  • Synonyms: cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); CBDCA; 1,1-Cyclobutanedicarboxylate diamine platinum(II);1,1-Cyclobutanedicarboxylatodiammineplatinum (II); cis-(1,1-Cyclobutanedicarboxylato)diamineplatinum(II);diammine(1,1-cyclobutanedicarboxylato)-platinum(I; Paraplatin;Carboplatin; Platinum, diamine(1,1-cyclobutanedicarboxylato(2-)-O,O')-,(SP-4-2)-; 1,1-Cyclobutanedicarboxylatodiammineplatinum; Carboplatin;
  • CAS Registry Number:
  • Transport: UN 2811
  • Flash Point: 189.6ºC
  • Boiling Point: 366.4ºCat 760 mmHg
  • Density: g/cm3
  • Water Solubility: Soluble
  • Safety Statements: R46;R61;R20/21;R42/43
  • Hazard Symbols: T: Toxic;
  • Flash Point: 189.6ºC
  • EINECS: 255-446-0
  • Molecular Weight: 371.25
  • InChI: InChI=1/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2/rC6H12N2O4Pt/c7-13(8)11-4(9)6(2-1-3-6)5(10)12-13/h1-3H2,7-8H3
  • Risk Statements: S53;S22;S26;S36/37/39;S45
  • Molecular Formula: C6H12N2O4Pt
  • Molecular Structure:CAS No:41575-94-4 Carboplatin

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References of Carboplatin
Title: Carboplatin
CAS Registry Number: 41575-94-4
CAS Name: (SP-4-2)-Diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]platinum
Synonyms: 1,1-cyclobutanedicarboxylic acid platinum complex; cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II); CBDCA
Manufacturers' Codes: JM-8; NSC-241240
Trademarks: Paraplatin (BMS)
Molecular Formula: C6H12N2O4Pt
Molecular Weight: 371.25
Percent Composition: C 19.41%, H 3.26%, N 7.55%, O 17.24%, Pt 52.55%
Literature References: Analog of cisplatin, q.v., with reduced nephrotoxicity. Prepn and antitumor activity: NL 7307863; M. J. Cleare et al., US 4140707 (1973, 1979 both to Research Corp.). Improved prepn: R. C. Harrison et al., Inorg. Chim. Acta 46, L15 (1980). Crystal structure: S. Neidle et al., J. Inorg. Biochem. 13, 205 (1980). Comparison with other antitumor platinum complexes: M. J. Cleare et al., Biochimie 60, 835 (1978). Early clinical studies: A. H. Calvert et al., Cancer Chemother. Pharmacol. 9, 140 (1982). Clinical pharmacokinetics: S. J. Harland et al., Cancer Res. 44, 1693 (1984); M. J. Egorin et al., ibid. 5432. Toxicity, activity in mice, rats, dogs: P. Lelieveld et al., Eur. J. Cancer Clin. Oncol. 20, 1087 (1984). Comparison with cisplatin chemotherapy in advanced seminoma: M. J. Peckham et al., Br. J. Cancer 52, 7 (1985). In treatment of small cell lung cancer: I. E. Smith et al., Cancer Treat. Rep. 69, 43 (1985).
Properties: White crystals, sol in water. LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld).
Toxicity data: LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Platinum Complexes.