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CAS No 40580-59-4 , 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine

  • Name: 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine
  • Synonyms: 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine; CHEBI:5555; Guanadrelum; Hylorel (TN); Guanadrel [INN]; Guanadrelum [INN-Latin]; Guanadrel sulfate;Hylorel;
  • CAS Registry Number:
  • Melting Point: 213.5-215 deg C
  • Flash Point: 188.4°C
  • Boiling Point: 387.9°C at 760 mmHg
  • Density: 1.39g/cm3
  • Refractive index: 1.618
  • Flash Point: 188.4°C
  • Molecular Weight: 213.27676
  • InchiKey: HPBNRIOWIXYZFK-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,
    (H4,11,12,13)
  • Molecular Formula: C10H19N3O2
  • Molecular Structure:CAS No:40580-59-4 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine

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References of 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine
Title: Guanadrel
CAS Registry Number: 40580-59-4
CAS Name: (1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine
Molecular Formula: C10H19N3O2
Molecular Weight: 213.28
Percent Composition: C 56.31%, H 8.98%, N 19.70%, O 15.00%
Literature References: Orally active postganglionic sympathetic inhibitor. Prepn: W. R. Hardie, J. E. Aaron, ZA 6706328; eidem, US 3547951 (1968, 1970 both to Cutter). Antihypertensive activity: L. Hansson et al., Clin. Pharmacol. Ther. 14, 204 (1973). In vitro adrenergic neuron blocking activity: L. Roller, Aust. J. Pharm. Sci. 5, 35 (1976). Pharmacologic study: E. M. Johnson, F. E. Hunter, Biochem. Pharmacol. 28, 1525 (1979). Effect on patients with thyrotoxicosis: S. Rubenfeld et al., Arch. Intern. Med. 138, 1106 (1978). Review of pharmacology and efficacy in hypertension: F. A. Finnerty Jr., R. N. Brogden, Drugs 30, 22-31 (1985).
 
Derivative Type: Sulfate
CAS Registry Number: 22195-34-2
Manufacturers' Codes: CL-1388R; U-28288D
Trademarks: Hylorel (Aventis)
Molecular Formula: (C10H19N3O2)2.H2SO4
Molecular Weight: 524.63
Percent Composition: C 45.79%, H 7.68%, N 16.02%, O 24.40%, S 6.11%
Properties: Cryst from methanol/ethanol, mp 213.5-215°.
Melting point: mp 213.5-215°
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Guanidine Derivatives.