CAS No 40507-23-1 , 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one

Name: 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
Synonyms: 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one; BRN 0891838; RF 46-790; Fluproquazona [INN-Spanish]; Fluproquazonum [INN-Latin]; SaH 46-790;Tormosyl;
CAS Registry Number:40507-23-1
Flash Point: 217.9°C
Boiling Point: 436.6°C at 760 mmHg
Density: 1.18g/cm³
Refractive index: 1.596
Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F− and NOx.
Flash Point: 217.9°C
Molecular Weight: 296.338783
InchiKey: ZWOUXWWGKJBAHQ-UHFFFAOYSA-N
InChI: InChI=1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-
7-14(19)8-6-13/h4-11H,1-3H3
Molecular Formula: C₁₈H₁₇FN₂O
Molecular Structure:

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References of 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one

Title: Fluproquazone
CAS Registry Number: 40507-23-1
CAS Name: 4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone
Synonyms: 1-isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone
Manufacturers' Codes: RF-46-790
Trademarks: Tormosyl
Molecular Formula: C18H17FN2O
Molecular Weight: 296.34
Percent Composition: C 72.95%, H 5.78%, F 6.41%, N 9.45%, O 5.40%
Literature References: Fluoro analog of proquazone, q.v. Prepn: G. E. Hardtmann et al., DE 2230393 (1973 to Sandoz), C.A. 78, 111363a (1973); G. E. Hardtmann, US 3937705 (1976 to Sandoz). Analgesic effect: U. Herrmann et al., Clin. Pharmacol. Ther. 27, 379 (1980); B. von Graffenried, E. Nuesch, Br. J. Clin. Pharmacol. 10, Suppl. 2, 225 (1980). Series of articles on pharmacology, metabolism, analysis, clinical studies, toxicology: Arzneim.-Forsch. 31, 871-940 (1981). Toxicity: G. Rüttimann et al., Arzneim.-Forsch. 31, 882 (1981).
Properties: Crystals, mp 172-174°. LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann).
Melting point: mp 172-174°
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann)
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).