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CAS No 40180-04-9 , 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid

  • Name: 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
  • Synonyms: Tienilic acid; Tienilico acido [Spanish]; Ticrex; Diflurex; Selacryn; Acide tienilique [INN-French]; Thienylic acid;2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid;
  • CAS Registry Number:
  • Melting Point: 148-149oC
  • Flash Point: 277.1°C
  • Boiling Point: 534.6°C at 760 mmHg
  • Density: 1.532g/cm3
  • Refractive index: 1.632
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, kidney damage and decreased urine volume or anuria. Mutation data reported. Used as a diuretic, uricosuric and antihypertensive. When heated to decomposition it emits toxic fumes of Cl− and SOx.
  • Flash Point: 277.1°C
  • EINECS: 254-826-3
  • Molecular Weight: 331.17122
  • InchiKey: AGHANLSBXUWXTB-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10
    (16)17/h1-5H,6H2,(H,16,17)
  • Molecular Formula: C13H8Cl2O4S
  • Molecular Structure:CAS No:40180-04-9 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid

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References of 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
Title: Ticrynafen
CAS Registry Number: 40180-04-9
CAS Name: [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
Synonyms: [2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy]acetic acid; tienilic acid; thienylic acid
Manufacturers' Codes: ANP-3624; CE-3624; SKF-62698
Trademarks: Diflurex (Anphar-Rolland); Selacryn (SKB)
Molecular Formula: C13H8Cl2O4S
Molecular Weight: 331.17
Percent Composition: C 47.15%, H 2.43%, Cl 21.41%, O 19.32%, S 9.68%
Literature References: A heterocyclic derivative of phenoxyacetic acid. Prepn: J. Godfroid, J. Thuillier, DE 2048372; US 3758506 (1971, 1973 both to C.E.R.P.H.A.) and FR 2115042 (1972 to C.E.R.P.H.A.). Synthesis and pharmacology: G. Thuillier et al., Eur. J. Med. Chem. 9, 625 (1974). Pharmacokinetics in healthy volunteers: A. L. Kerremans et al., Eur. J. Clin. Pharmacol. 22, 515 (1982). Comparative study in hypertensive patients: B. T. Emmerson et al., ibid. 203. Hepatotoxicity study: J. W. Manier et al., Am. J. Gastroenterol. 77, 401 (1982).
Properties: Crystals from 50% ethanol, mp 148-149°; also reported as mp 157°. LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506).
Melting point: mp 148-149°; mp 157°
Toxicity data: LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506)
Therap-Cat: Diuretic; uricosuric; antihypertensive.
Keywords: Antihypertensive; Diuretic; Uricosuric.