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CAS No 4008-48-4 , 5-nitroquinolin-8-ol Search by region : China

  • Name: 5-nitroquinolin-8-ol
  • Synonyms: 5-nitroquinolin-8-ol; NITROXOLINE; 4008-48-4; 5-Nitro-8-quinolinol; Noxibiol; 5-nitroquinolin-8-ol; Nitroxolin;8-Hydroxy-5-nitroquinoline; Noxin; 5-Nitro-8-hydroxyquinoline;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 181-183 ºC
  • Flash Point: 419 °C at 760mmHg
  • Boiling Point: 419 °C at 760mmHg
  • Density: 1.496 g/cm3
  • Refractive index: 1.728
  • Safety Statements: R22/24/25;R36/37/38
  • Hazard Symbols: T: Toxic;
  • Flash Point: 419 °C at 760mmHg
  • EINECS: 223-662-4
  • Molecular Weight: 190.15554
  • InchiKey: RJIWZDNTCBHXAL-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
  • Risk Statements: S26;S36;S45
  • Molecular Formula: C9H6N2O3
  • Molecular Structure:CAS No:4008-48-4 5-nitroquinolin-8-ol

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References of 5-nitroquinolin-8-ol
Title: Nitroxoline
CAS Registry Number: 4008-48-4
CAS Name: 5-Nitro-8-quinolinol
Synonyms: 5-nitro-8-hydroxyquinoline
Trademarks: Enterocol; Nibiol; Noxibiol; Uritrol; Urocoli
Molecular Formula: C9H6N2O3
Molecular Weight: 190.16
Percent Composition: C 56.84%, H 3.18%, N 14.73%, O 25.24%
Literature References: Prepn: Kostanecki, Ber. 24, 154 (1891); Petrow, Sturgeon, J. Chem. Soc. 1954, 570; Pratt, Duke, J. Am. Chem. Soc. 82, 1155 (1960). In vitro antibacterial and antifungal activity: A. Desvignes, P. Leguen, Ann. Pharm. Fr. 21, 803 (1963); M. Medic-Saric et al., Chemotherapy 26, 263 (1980). Toxicological study: O. Angelova et al., Adv. Antimicrob. Antineoplast. Chemother., Proc. 7th Int. Congr. Chemother. 1, 507 (1972). Clinical pharmacokinetics: A. Mrhar et al., Int. J. Clin. Pharmacol. Biopharm. 17, 476 (1979). HPLC determn in plasma and urine: R. H. A. Sorel et al., J. Chromatogr. 222, 241 (1981). Clinical evaluation in urinary tract infections: M. R. Jacobs et al., S. Afr. Med. J. 54, 959 (1978); B. Cancet, A. Amgar, Pathol. Biol. 35, 879 (1987).
Properties: Yellow needles from alcohol or acetic acid, mp 179.5-181.5°. Freely sol in alkali and hot HCl; sparingly sol in alcohol, ether.
Melting point: mp 179.5-181.5°
 
Derivative Type: Hydrochloride
Molecular Formula: C9H7ClN2O3
Molecular Weight: 226.62
Percent Composition: C 47.70%, H 3.11%, Cl 15.64%, N 12.36%, O 21.18%
Properties: Yellow needles from alcohol, mp 258°.
Melting point: mp 258°
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic).