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CAS No 396-01-0 , 6-phenylpteridine-2,4,7-triamine Search by region : China

  • Name: 6-phenylpteridine-2,4,7-triamine
  • Synonyms: Jatropur; Triampur; Noridil;Dyrenium; Pterofen;6-phenylpteridine-2,4,7-triamine; Dytac; Pterophene; Ademin; Taturil;
  • CAS Registry Number:
  • Transport: 2811
  • Melting Point: 316 ºC
  • Density: 1.502 g/cm3
  • Water Solubility: <0.1 G/100 ML AT 20 ºC
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 206-904-3
  • Molecular Weight: 253.26264
  • InchiKey: FNYLWPVRPXGIIP-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-
    9/h1-5H,(H6,13,14,15,17,18,19)
  • Risk Statements: S26;S36/37/39
  • Molecular Formula: C12H11N7
  • Molecular Structure:CAS No:396-01-0 6-phenylpteridine-2,4,7-triamine

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References of 6-phenylpteridine-2,4,7-triamine
Title: Triamterene
CAS Registry Number: 396-01-0
CAS Name: 6-Phenyl-2,4,7-pteridinetriamine
Synonyms: 2,4,7-triamino-6-phenylpteridine; 6-phenyl-2,4,7-triaminopteridine; ademin(e); pterofen; pterophene
Manufacturers' Codes: NSC-77625; SKF-8542
Trademarks: Dyren (Sejin); Dyrenium (SKB); Dytac (Bridge); Jatropur (Procter & Gamble); Teriam (Roussel Diamant); Triteren (Sumitomo); Urocaudal (Jorba)
Molecular Formula: C12H11N7
Molecular Weight: 253.26
Percent Composition: C 56.91%, H 4.38%, N 38.71%
Literature References: Prepn: Spickett, Timmis, J. Chem. Soc. 1954, 2887; Pachter, J. Org. Chem. 28, 1191 (1963); Weinstock, Wiebelhaus, US 3081230 (1963 to SK & F); Osdene et al., J. Med. Chem. 10, 431 (1967). Review: Ther. Triamteren Wien. Symp. 1966, K. Fellinger, Ed. (Georg Thieme, Vienna, 1967). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. Excip. 23, 571-605 (1994).
Properties: Yellow plates from butanol, mp 316° (Spickett, Timmis); also reported as crystals from DMF, mp 327° (Osdene et al.). pKa 6.2. Practically insol in ether. Sol in formic acid. Slight sol in water (1 in 1000), ethanol (1 in 3000), chloroform (1 in 4000). uv max (4.5% formic acid): 356 nm (e 21000).
Melting point: mp 316° (Spickett, Timmis); mp 327° (Osdene et al.)
pKa: pKa 6.2
Absorption maximum: uv max (4.5% formic acid): 356 nm (e 21000)
Therap-Cat: Diuretic.
Keywords: Diuretic.