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CAS No 39379-15-2 , Neurotensin

  • Name: Neurotensin
  • Synonyms: PyrLeuTyrGluAsnLysProArgArgProTyrIleLeuOH;Neurotensin;
  • CAS Registry Number:
  • Density: 1.46g/cm3
  • Refractive index: 1.666
  • Molecular Weight: 1672.92
  • InChI: InChI=1/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)
  • Molecular Formula: C78H121N21O20
  • Molecular Structure:CAS No:39379-15-2 Neurotensin

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39379-15-2 NEUROTENSIN

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
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39379-15-2 330298 NEUROTENSIN, GUINEA PIG H-PGLU-LEU-TYR-GLU-ASN-LYS-SER-ARG-ARG-PRO-TYR-ILE-LEU-OH

  • Germany chemcube UG [Manufacturer]
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  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany null,nullGermany
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39379-15-2 NEUROTENSIN

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
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References of Neurotensin
Title: Neurotensin
CAS Registry Number: 39379-15-2
Literature References: A basic tridecapeptide, found in mammalian brain and gut, having a wide variety of hormone-like activities. Neurotensin has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as a CNS neurotransmitter. Isoln from bovine hypothalamus: R. Carraway, S. Leeman, J. Biol. Chem. 248, 6854 (1973). Amino acid sequence of bovine neurotensin: eidem, ibid. 250, 1907 (1975). Synthesis: eidem, ibid. 1912; K. Kitagawa et al., Chem. Pharm. Bull. 24, 2692 (1976); H. Yajima et al., Int. J. Pept. Protein Res. 14, 169 (1979). Isoln, amino acid sequence of chicken neurotensin: R. Carraway, Y. M. Bhatnagar, Peptides 1, 167 (1980). Synthesis: H. Yajima et al., Chem. Pharm. Bull. 29, 2587 (1981). Radioimmunoassay and differential distribution of bovine neurotensin in CNS, small intestine, and stomach: R. Carraway, S. Leeman, J. Biol. Chem. 251, 7035, 7045 (1976). CNS effects: C. B. Nemeroff et al., Brain Res. 128, 485 (1977). Receptor binding in brain: G. R. Uhl et al., ibid. 130, 299 (1977). Pharmacokinetics and effect on gastrointestinal and pituitary hormones in man: A. M. Blackburn et al., J. Clin. Endocrinol. Metab. 51, 1257 (1980). Reviews of biological activity: G. R. Uhl, S. H. Snyder, Adv. Biochem. Psychopharmacol. 28, 87-106 (1981); D. R. Brown, R. J. Miller, Annu. Rep. Med. Chem. 17, 271-280 (1982). Book: Ann. N.Y. Acad. Sci. 400, entitled "Neurotensin, a Brain and Gastrointestinal Peptide", C. B. Nemeroff, A. J. Prange, Eds. (1982) pp 1-444.
 
Derivative Type: Bovine neurotensin triacetate hexahydrate
Synonyms: Neurotensin (ox) triacetate (salt)
Molecular Formula: C84H133N21O26.6H2O
Molecular Weight: 1961.17
Percent Composition: C 51.44%, H 7.45%, N 15.00%, O 26.11%
Properties: Fluffy white powder. [a]D23 -65.6° (c = 0.5 in water).
Optical Rotation: [a]D23 -65.6° (c = 0.5 in water)