CAS No 38957-41-4 , 4-ethoxy-2-methyl-5-morpholin-4-ylpyridazin-3-one

Name: 4-ethoxy-2-methyl-5-morpholin-4-ylpyridazin-3-one
Synonyms: Emorfazona [INN-Spanish]; 38957-41-4; Emorfazone [INN-French];Nandron; EINECS 254-220-9; emorfazone(jan); Emorfazonum [INN-Latin];4-ethoxy-2-methyl-5-morpholin-4-ylpyridazin-3-one;
CAS Registry Number:38957-41-4
Flash Point: 175.4°C
Boiling Point: 366.5°C at 760 mmHg
Density: 1.27g/cm³
Refractive index: 1.579
Safety Statements: Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Flash Point: 175.4°C
EINECS: 254-220-9
Molecular Weight: 239.27098
InchiKey: URJQOOISAKEBKW-UHFFFAOYSA-N
InChI: InChI=1S/C11H17N3O3/c1-3-17-10-9(8-12-13(2)11(10)15)14-4-6-16-7-5-14/
h8H,3-7H2,1-2H3
Molecular Formula: C₁₁H₁₇N₃O₃
Molecular Structure:

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References of 4-ethoxy-2-methyl-5-morpholin-4-ylpyridazin-3-one

Title: Emorfazone
CAS Registry Number: 38957-41-4
CAS Name: 4-Ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone
Manufacturers' Codes: M-73101
Trademarks: Nandron (Morishita); Pentoyl (Morishita)
Molecular Formula: C11H17N3O3
Molecular Weight: 239.27
Percent Composition: C 55.22%, H 7.16%, N 17.56%, O 20.06%
Literature References: Prepn: K. Satoda et al., JP 72 24030 (1972 to Morishita), C.A. 77, 164732f (1972); M. Takaya et al., J. Med. Chem. 22, 53 (1979). Metabolism studies: T. Hayashi et al., Chem. Pharm. Bull. 26, 3124 (1978); 27, 317 (1979). General pharmacological study: M. Sato et al., Nippon Yakurigaku Zasshi 75, 291 (1979), C.A. 91, 117292 (1979). Mechanism of action studies: M. Sato, A. Yamaguchi, Arzneim.-Forsch. 32, 379 (1982). Antigenicity study: M. Sato et al., Oyo Yakuri 18, 65 (1979), C.A. 92, 104391 (1980). Toxicity studies: eidem, ibid. 16, 1011 (1978), C.A. 90, 197741 (1979); C. Onodera et al., J. Toxicol. Sci. 4, 229 (1979); K. Shimpo et al., ibid. 255.
Properties: Cryst from methanol/isopropyl ether, mp 89-91°. LD50 i.p. in mice: 700 mg/kg (Takaya).
Melting point: mp 89-91°
Toxicity data: LD50 i.p. in mice: 700 mg/kg (Takaya)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal).