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CAS No 38677-81-5 , 2,6-Pyridinedimethanol,R6-[[(1,1-dimethylethyl) amino]methyl]-3-hydroxy-

  • Name: 2,6-Pyridinedimethanol,R6-[[(1,1-dimethylethyl) amino]methyl]-3-hydroxy-
  • Synonyms: 2,6-Pyridinedimethanol,R6-[[(1,1-dimethylethyl) amino]methyl]-3-hydroxy- ;2-tert-Butylamino-1-(5-hydroxy-6-hydroxymethyl-2-pyridyl)ethanol;6-[2-(tert-Butylamino)-1-hydroxyethyl]-3-hydroxy-2-pyridinemethanol;2,6-Pyridinedimethanol, a6-[[(1,1-dimethylethyl)amino]methyl]-3-hydroxy- (9CI);Pirbuterol;
  • CAS Registry Number:
  • Flash Point: 249.7°C
  • Boiling Point: 489.3°Cat760mmHg
  • Density: 1.196g/cm3
  • Refractive index: 1.569
  • Flash Point: 249.7°C
  • Molecular Weight: 0
  • InChI: InChI=1/C12H20N2O3/c1-12(2,3)13-6-11(17)8-4-5-10(16)9(7-15)14-8/h4-5,11,13,15-17H,6-7H2,1-3H3
  • Molecular Formula: C12H22Cl2N2O3
  • Molecular Structure:CAS No:38677-81-5 2,6-Pyridinedimethanol,R6-[[(1,1-dimethylethyl) amino]methyl]-3-hydroxy-

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References of 2,6-Pyridinedimethanol,R6-[[(1,1-dimethylethyl) amino]methyl]-3-hydroxy-
Title: Pirbuterol
CAS Registry Number: 38677-81-5
CAS Name: a6-[[(1,1-Dimethylethyl)amino]methyl]-3-hydroxy-2,6-pyridinedimethanol
Synonyms: 2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-tert-butylaminoethyl)pyridine
Molecular Formula: C12H20N2O3
Molecular Weight: 240.30
Percent Composition: C 59.98%, H 8.39%, N 11.66%, O 19.97%
Literature References: Analog of albuterol, q.v., with b2-adrenergic stimulating activity. Prepn: W. E. Barth, DE 2204195; idem, US 3700681 (both 1972 to Pfizer). Stability study: P. C. Bansal, D. C. Monkhouse, J. Pharm. Sci. 66, 819 (1977). Biotransformation: H. M. McIlhenny, M. S. D. Ghaly, Fed. Proc. 38, 1130 (1979). Pharmacokinetics and cardiopulmonary effects in dogs: J. W. Constantine et al., J. Pharmacol. Exp. Ther. 208, 371 (1979). Comparative study in respiratory disease: A. J. Dyson, A. D. Mackay, Br. J. Dis. Chest 74, 70 (1980). Use in treatment of cardiac failure: N. A. Awan et al., Clin. Res. 28, 17A (1980); W. S. Colucci et al., N. Engl. J. Med. 305, 185 (1981); G. I. Nelson et al., Eur. Heart J. 3, 238 (1982); K. T. Weber et al., Circulation 66, 1262 (1982). Review of pharmacology and efficacy in bronchospastic disease: D. M. Richards, R. N. Brogden, Drugs 30, 6-21 (1985).
 
Derivative Type: Dihydrochloride
CAS Registry Number: 38029-10-6
Manufacturers' Codes: CP-24314-1
Molecular Formula: C12H22Cl2N2O3
Molecular Weight: 313.22
Percent Composition: C 46.02%, H 7.08%, Cl 22.64%, N 8.94%, O 15.32%
Properties: Crystals from ethanol/isopropyl ether, mp 182° (dec).
Melting point: mp 182° (dec)
 
Derivative Type: Monoacetate
Trademarks: Maxair (3M Pharma); Spirolair (3M Pharma)
Molecular Formula: C14H24N2O5
Molecular Weight: 300.35
Percent Composition: C 55.98%, H 8.05%, N 9.33%, O 26.63%
Properties: Freely sol in water.
 
Therap-Cat: Bronchodilator.
Keywords: ?Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives.