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CAS No 382-67-2 , Desoximetasone

  • Name: Desoximetasone
  • Synonyms: 21-Desoxybetamethasone;Desoximetasone; 9-Fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione;-;
  • CAS Registry Number:
  • Melting Point: 217
  • Flash Point: 275.7°C
  • Boiling Point: 532.3°Cat760mmHg
  • Density: 1.25g/cm3
  • Refractive index: 1.574
  • Safety Statements: R20/21/22;R36/37/38;R40;R43
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 275.7°C
  • EINECS: 206-845-3
  • Molecular Weight: 376.47
  • InChI: InChI=1/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15?,16?,18?,19?,20?,21?,22+/m1/s1
  • Risk Statements: S22;S26;S36
  • Molecular Formula: C22H29FO4
  • Molecular Structure:CAS No:382-67-2 Desoximetasone

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References of Desoximetasone
Title: Desoximetasone
CAS Registry Number: 382-67-2
CAS Name: (11b,16a)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 9a-fluoro-16a-methyl-17-desoxyprednisolone; 9a-fluoro-16a-methyl-D1-corticosterone; desoxymethasone
Manufacturers' Codes: A-41-304; R-2113; HOE-304
Trademarks: Esperson (HMR); Stiedex LP (Stiefel); Topicort (HMR); Topisolon (HMR)
Molecular Formula: C22H29FO4
Molecular Weight: 376.46
Percent Composition: C 70.19%, H 7.76%, F 5.05%, O 17.00%
Literature References: Prepn: R. Joly et al., FR 1296544; eidem, US 3099654 (1962, 1963 to Roussel-UCLAF); BE 614196; Kieslich et al., US 3232839 (1962, 1966 to Schering AG); R. Joly et al., Arzneim.-Forsch. 24, 1 (1974). Activity studies: Branceni et al., Steroids 6, 451 (1965); Schr?der et al., Arzneim.-Forsch. 24, 3 (1974). NMR data: Lukacs et al., C.R. Seances Acad. Sci. Ser. C 274, 1458 (1972). Review of pharmacology and therapeutic efficacy in dermatoses: R. C. Heel et al., Drugs 16, 302-321 (1978).
Properties: Crystals from ethyl acetate, mp 217°. [a]D +109° (chloroform). uv max: 238 nm (e 15750). Sol in alcohol, acetone, chloroform, hot ethyl acetate; slightly sol in ether, benzene. Insol in water, dil aq acids and alkalies.
Melting point: mp 217°
Optical Rotation: [a]D +109° (chloroform)
Absorption maximum: uv max: 238 nm (e 15750)
Therap-Cat: Anti-inflammatory; glucocorticoid.
Keywords: Glucocorticoid.