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CAS No 37517-28-5 , Amikacin Search by region : China

  • Name: Amikacin
  • Synonyms: Amikacin;-;
  • CAS Registry Number:
  • Melting Point: 203-204 deg C (sesquihydrate)
  • Density: 1.6 g/cm3
  • Refractive index: 1.663
  • Water Solubility: H2O: 50 mg/mL, clear, colorless
  • Safety Statements: 26-36
  • Hazard Symbols: Xi
  • EINECS: 253-538-5
  • Molecular Weight: 585.6
  • InChI: InChI=1/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C22H43N5O13
  • Molecular Structure:CAS No:37517-28-5 Amikacin

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37517-28-5 Amikacin

  • Amikacin
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
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  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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37517-28-5 Amikacin Base

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  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
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  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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37517-28-5 Amikacin Base

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  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
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  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,nullChina
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37517-28-5 Amikacin

  • AmikacinAmikacin, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
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37517-28-5 Amikacin

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37517-28-5 amikacin Sulphate

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37517-28-5 Amikacin

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  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
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37517-28-5 Amikacin Base

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
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References of Amikacin
Title: Amikacin
CAS Registry Number: 37517-28-5
CAS Name: O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[6-amino-6-deoxy-a-D-glucopyranosyl-(1?4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine
Synonyms: 1-N-[L(-)-4-amino-2-hydroxybutyryl]kanamycin A
Molecular Formula: C22H43N5O13
Molecular Weight: 585.60
Percent Composition: C 45.12%, H 7.40%, N 11.96%, O 35.52%
Literature References: Semisynthetic aminoglycoside antibiotic derived from kanamycin A. Prepn: Kawaguchi et al., J. Antibiot. 25, 695 (1972); H. Kawaguchi, T. Naito, DE 2234315; H. Kawaguchi et al., US 3781268 (both 1973 to Bristol-Myers). Biological formation from kanamycin A: L. M. Cappelletti, R. Spagnoli, J. Antibiot. 36, 328 (1983). Microbiological evaluation: Price et al., ibid. 25, 709 (1972). Pharmacokinetics: Cabana, Taggart, Antimicrob. Agents Chemother. 3, 478 (1973). In vitro studies: Yu, Washington, ibid. 4, 133 (1973); Bodey, Stewart, ibid. 186. Pharmacology in humans: Bodey et al., ibid. 5, 508 (1974). Toxicity studies: Fujisawa et al., J. Antibiot. 27, 677 (1974). Review: K. A. Kerridge in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 125-153. Comprehensive description: P. M. Monteleone et al., Anal. Profiles Drug Subs. 12, 37-71 (1983).
Properties: White crystalline powder from methanol-isopropanol, mp 203-204° (sesquihydrate). [a]D23 +99° (c = 1.0 in water). LD50 in mice of solns pH 6.6, pH 7.4 (mg/kg): 340, 560 i.v. (Kawaguchi).
Melting point: mp 203-204° (sesquihydrate)
Optical Rotation: [a]D23 +99° (c = 1.0 in water)
Toxicity data: LD50 in mice of solns pH 6.6, pH 7.4 (mg/kg): 340, 560 i.v. (Kawaguchi)
 
Derivative Type: Sulfate
CAS Registry Number: 39831-55-5
Trademarks: Amiglyde-V (Fort Dodge); Amikin (BMS); Amiklin (BMS); BB-K8 (BMS); Biklin (BMS); Lukadin (San Carlo); Mikavir (Salus); Novamin (BMS); Pierami (Fournier)
Molecular Formula: C22H43N5O13.2H2SO4
Molecular Weight: 781.76
Percent Composition: C 33.80%, H 6.06%, N 8.96%, O 42.98%, S 8.20%
Properties: Amorphous form, dec 220-230°. [a]D22 +74.75° (water).
Optical Rotation: [a]D22 +74.75° (water)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.