References of (7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,13,17-trimethyl-1,2,6,7,8,9,10,
11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Title: Mibolerone
CAS Registry Number: 3704-09-4
CAS Name: (7a,17b)-17-Hydroxy-7,17-dimethylestr-4-en-3-one
Synonyms: 7a,17a-dimethyl-19-nortestosterone
Manufacturers' Codes: U-10997
Trademarks: Cheque
Molecular Formula: C20H30O2
Molecular Weight: 302.45
Percent Composition: C 79.42%, H 10.00%, O 10.58%
Literature References: Synthetic anabolic steroid related to testosterone,
q.v. Prepn:
BE 610385; J. C. Babcock, J. A. Campbell,
US 3341557 (1962, 1967 both to Upjohn). Biological properties: J. A. Campbell
et al., Steroids 1, 317 (1963). Dissolution and solubility rates: W. E. Hamlin
et al., J. Pharm. Sci. 54, 1651 (1965). Pharmacodynamics: J. H. Sokolowski, C. W. Kasson,
Am. J. Vet. Res. 39, 837 (1978). Efficacy evaluation in dogs: J. H. Sokolowski,
J. Am. Vet. Med. Assoc. 173, 983 (1978).
Properties: Cryst solid. Soly in deionized water: 0.0454 mg/ml at 37°.
NOTE: This is a controlled substance (anabolic steroid):
21 CFR, 1308.13, as defined in 1300.01.
Therap-Cat-Vet: Antigonadotropic used to suppress estrus.