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CAS No 36791-04-5 , Ribavirin

  • Name: Ribavirin
  • Synonyms: Ribavirin; Tribavirin; rtca; vilona; tribavirin;Ribavirin; Vilona;Biopolymers; virazole;1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; RTCA; Biopolymers; viramid; Virazole; virazid; Virazid; Viramid; 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide; ICN-1229;
  • CAS Registry Number:
  • Melting Point: 174-176 ºC
  • Flash Point: 340.7ºC
  • Boiling Point: 639.8 ºC at 760 mmHg
  • Density: 2.08 g/cm3
  • Refractive index: -36 ° (C=1, H2O)
  • Water Solubility: >=10 G/100 ML AT 19 ºC
  • Safety Statements: Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as an antiviral agent. When heated to decomposition it emits toxic fumes of NOx.Analytical Methods:   For occupational chemical analysis use NIOSH: Ribavirin 5027.
  • Hazard Symbols: Mildly toxic by ingestion. An experimental teratogen.
  • Flash Point: 340.7ºC
  • Molecular Weight: 244.21
  • InChI: InChI=1/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
  • Risk Statements: 61
  • Molecular Formula: C8H12N4O5
  • Molecular Structure:CAS No:36791-04-5 Ribavirin

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References of Ribavirin
Title: Ribavirin
CAS Registry Number: 36791-04-5
CAS Name: 1-b-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
Synonyms: RTCA; tribavirin
Manufacturers' Codes: ICN-1229
Trademarks: Copegus (Roche); Rebetol (Schering-Plough); Viramid (Alfa); Virazide (Valeant); Virazole (Valeant)
Molecular Formula: C8H12N4O5
Molecular Weight: 244.20
Percent Composition: C 39.35%, H 4.95%, N 22.94%, O 32.76%
Literature References: Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Prepn: J. T. Witkowski, R. Robins, DE 2220246; eidem, US 3798209 (1972, 1974 both to ICN); J. T. Witkowski et al., J. Med. Chem. 15, 1150 (1972); eidem, J. Carbohydr. Nucleosides Nucleotides 5, 363 (1978). Regioselective synthesis: Y. Ito et al., Tetrahedron Lett. 1979, 2521. NMR study: G. P. Kreishman et al., J. Am. Chem. Soc. 94, 5894 (1972). Crystal structure: P. Prusiner, M. Sundaralingam, Nature New Biol. 244, 116 (1973). Teratogenicity study: D. M. Kochhar et al., Toxicol. Appl. Pharmacol. 52, 99 (1980). Review of antiviral activity: R. W. Sidwell et al., Pharmacol. Ther. 6, 123-146 (1979); of clinical experience: H. Fernandez et al., Eur. J. Epidemiol. 2, 1-14 (1986); of molecular modes of action: J. L. Patterson, R. Fernandez-Larsson, Rev. Infect. Dis. 12, 1139-1146 (1990). Clinical trial in infants with respiratory syncytial viral infection: C. B. Hall et al., N. Engl. J. Med. 308, 1443 (1983); in combination with interferon alfa-2b in hepatitis C: O. Reichard et al., Lancet 351, 83 (1998).
Properties: White to off-white powder. Freely sol in water; slightly sol in anhydrous alcohol. Exists in two polymorphic forms: mp 166-168° (aq ethanol); mp 174-176° (ethanol) (Witkowski, 1972). Also reported as mp 180-182° (Ito). [a]D25 -36.5° (c = 1 in water); [a]D20 -38° (c = 1 in water). LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972).
Melting point: mp 166-168° (aq ethanol); mp 174-176° (ethanol) (Witkowski, 1972); mp 180-182° (Ito)
Optical Rotation: [a]D25 -36.5° (c = 1 in water); [a]D20 -38° (c = 1 in water)
Toxicity data: LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)
Therap-Cat: Antiviral.
Keywords: Antiviral; IMPDH Inhibitor.