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CAS No 36364-49-5 , Imidazoli salicylas [Latin]

  • Name: Imidazoli salicylas [Latin]
  • Synonyms: imidazole-2-hydroxybenzoate;Imidazoli salicylas [Latin];
  • CAS Registry Number:
  • Flash Point: 144.5°C
  • Boiling Point: 336.3°Cat760mmHg
  • Density: g/cm3
  • Flash Point: 144.5°C
  • Molecular Weight: 206.201
  • InChI: InChI=1/C7H6O3.C3H4N2/c8-6-4-2-1-3-5(6)7(9)10;1-2-5-3-4-1/h1-4,8H,(H,9,10);1-3H,(H,4,5)
  • Molecular Formula: C10H10N2O3
  • Molecular Structure:CAS No:36364-49-5 Imidazoli salicylas [Latin]

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36364-49-5 Imidazoli salicylas [Latin]

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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36364-49-5 Imidazoli salicylas [Latin]

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36364-49-5 IMIDAZOLE SALICYLATE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Imidazoli salicylas [Latin]
Title: Imidazole Salicylate
CAS Registry Number: 36364-49-5
CAS Name: 2-Hydroxybenzoic acid compd with 1H-imidazole (1:1)
Synonyms: mono(2-hydroxybenzoate)-1H-imidazole; salizolo
Manufacturers' Codes: ITF-182
Trademarks: Flogozen (SPA); Selezen (Italfarmaco)
Molecular Formula: C10H10N2O3
Molecular Weight: 206.20
Percent Composition: C 58.25%, H 4.89%, N 13.59%, O 23.28%
Literature References: Prepn from equimolar amounts of salicylic acid with imidazole: M. Brissemoret, Bull. Soc. Chim. Fr. [3] 35, 316 (1906). Use as anti-inflammatory agent: BE 889704; G. Sportoletti, US 4329340 (1981, 1982 both to Italfarmaco). Pharmacology: P. G. Pagella et al., Arzneim.-Forsch. 33, 716 (1983). Penetration of inflamed sites: eidem, ibid. 34, 208 (1984). Pharmacokinetics: H. P. Kuemmerle et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 22, 521 (1984). Series of clinical studies: Boll. Chim. Farm. 122, 37S-63S (1983). Review: R. Fantozzi, Drugs Exp. Clin. Res. 10, 853-856 (1984).
Properties: Crystals from methanol-ether, mp 123-124°. uv max: 300 nm (E1%1cm 182.5). Soly in water >100 mg/cc. LD50 in male, female rats, mice (mg/kg): 763, 724, 595, 685 s.c.; 422, 434, 462, 435 i.v.; 1211, 1430, 1034, 1091 orally (Pagella).
Melting point: mp 123-124°
Absorption maximum: uv max: 300 nm (E1%1cm 182.5)
Toxicity data: LD50 in male, female rats, mice (mg/kg): 763, 724, 595, 685 s.c.; 422, 434, 462, 435 i.v.; 1211, 1430, 1034, 1091 orally (Pagella)
Therap-Cat: Anti-inflammatory; antipyretic; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic.