Home > Name List By other > (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate

CAS No 35795-16-5 , (2-hydroxy-2-methylpropyl)
4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate

  • Name: (2-hydroxy-2-methylpropyl)
    4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate
  • Synonyms: Trimazosine [INN-French]; EINECS 252-732-7;Trimazosin [INN:BAN]; 35795-16-5;(2-hydroxy-2-methylpropyl)
    4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate; Trimazosino [INN-Spanish]; Trimazosinum [INN-Latin];
  • CAS Registry Number:
  • Flash Point: 345.8°C
  • Boiling Point: 648.2°Cat760mmHg
  • Density: 1.31g/cm3
  • Refractive index: 1.606
  • Flash Point: 345.8°C
  • EINECS: 252-732-7
  • Molecular Weight: 435.47416
  • InchiKey: YNZXWQJZEDLQEG-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H29N5O6/c1-20(2,
    27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15
    (29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23)
  • Molecular Formula: C20H29N5O6
  • Molecular Structure:CAS No:35795-16-5 (2-hydroxy-2-methylpropyl)<br />4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate

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References of (2-hydroxy-2-methylpropyl)
4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate
Title: Trimazosin
CAS Registry Number: 35795-16-5
CAS Name: 4-(4-Amino-6,7,8-trimethoxy-2-quinazolinyl)-1-piperazinecarboxylic acid 2-hydroxy-2-methylpropyl ester
Molecular Formula: C20H29N5O6
Molecular Weight: 435.47
Percent Composition: C 55.16%, H 6.71%, N 16.08%, O 22.04%
Literature References: Prepn: H. J. Hess, DE 2120495 corresp to US 3669968 (1971, 1972 both to Pfizer). Pharmacological study in rats: J. P. Buyniski et al., Clin. Exp. Hypertens. 2, 1039 (1980), C.A. 94, 76779x (1981). Cardiocirculatory effects in congestive heart failure: N. A. Awan et al., Am. J. Cardiol. 44, 126 (1979). Long-term therapeutic use: K. T. Weber et al., N. Engl. J. Med. 303, 242 (1980).
Properties: White cryst from chloroform/diisopropyl ether, mp 158-159°.
Melting point: mp 158-159°
 
Derivative Type: Hydrochloride monohydrate
CAS Registry Number: 53746-46-6
Manufacturers' Codes: CP-19106-1
Trademarks: Supres (Pfizer)
Molecular Formula: C20H29N5O6.HCl.H2O
Molecular Weight: 489.95
Percent Composition: C 49.03%, H 6.58%, N 14.29%, O 22.86%, Cl 7.24%
Properties: White cryst, mp 166-169° (dec).
Melting point: mp 166-169° (dec)
 
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Blocker; Antihypertensive; Quinazoline Derivatives.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.