Home > Name List By other > (6R, 7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic a...

CAS No 3577-01-3 , (6R,
7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-
thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Name: (6R,
    7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-
    thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Synonyms: Cefaloglicina; Cephaoglycin acid; D-Cephaloglycine; Cefaloglycine;(6R,
    7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-
    thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Kafocin; Cephaloglycin anhydrous; Cephaloglycine;Cefaloglycin; Kefglycin;
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Refractive index: 1.678
  • Safety Statements: Moderately toxic by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • EINECS: 222-696-7
  • Molecular Weight: 405.42496
  • InchiKey: FUBBGQLTSCSAON-PBFPGSCMSA-N
  • InChI: InChI=1S/C18H19N3O6S/c1-9(22)27-7-11-8-28-17-13(16(24)21(17)14(11)18(25)
    26)20-15(23)12(19)10-5-3-2-4-6-10/h2-6,12-13,17H,7-8,19H2,1H3,(H,20,
    23)(H,25,26)/t12-,13-,17-/m1/s1
  • Molecular Formula: C18H19N3O6S
  • Molecular Structure:CAS No:3577-01-3 (6R,<br />7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-<br />thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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3577-01-3 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-,(6R,7R)-

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References of (6R,
7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-
thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Title: Cephaloglycin
CAS Registry Number: 3577-01-3
CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2R)-aminophenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 7-(2-amino-2-phenylacetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid acetate (ester); 7-(D-2-amino-2-phenylacetamido)-3-acetoxymethyl-D3-cephem-4-carboxylic acid; 7-(D-a-aminophenylacetamido) cephalosporanic acid
Trademarks: Kefglycin (Lilly)
Molecular Formula: C18H19N3O6S
Molecular Weight: 405.42
Percent Composition: C 53.33%, H 4.72%, N 10.36%, O 23.68%, S 7.91%
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: BE 635137; F. W. Wall et al., US 3422103 (1964, 1969 both to Glaxo); GB 1017624 (1966 to Merck & Co.); Spencer et al., J. Med. Chem. 9, 746 (1966); of D- and DL-forms: GB 985747 (1965 to Lilly); Kurita et al., J. Antibiot. 19A, 243 (1966). Metabolism and pharmacokinetics in man: J. Haginaka et al., J. Antibiot. 33, 236 (1980).
 
Derivative Type: Dihydrate
CAS Registry Number: 22202-75-1
Trademarks: Kafocin (Lilly)
Properties: Crystalline powder, mp 223-250° (dec). uv max (2% DMF): 258 nm (E1%1cm 166). Isoelectric point and pH of maximum stability: 4.5.
Melting point: mp 223-250° (dec)
Absorption maximum: uv max (2% DMF): 258 nm (E1%1cm 166)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.