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CAS No 34866-47-2 , [5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea

  • Name: [5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea
  • Synonyms: 34866-47-2; SK&F 40383; Carbuterolum;Carbuterolum [INN-Latin]; EINECS 252-257-5;[5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea; SK&F-40383;
  • CAS Registry Number:
  • Flash Point: 224.4°C
  • Boiling Point: 447.4°Cat760mmHg
  • Density: 1.248g/cm3
  • Refractive index: 1.612
  • Flash Point: 224.4°C
  • EINECS: 252-257-5
  • Molecular Weight: 267.32414
  • InchiKey: KEMXXQOFIRIICG-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H21N3O3/c1-13(2,
    3)15-7-11(18)8-4-5-10(17)9(6-8)16-12(14)19/h4-6,11,15,17-18H,7H2,1-3H3,
    (H3,14,16,19)
  • Molecular Formula: C13H21N3O3
  • Molecular Structure:CAS No:34866-47-2 [5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea

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34866-47-2 Urea,N-[5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-

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References of [5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea
Title: Carbuterol
CAS Registry Number: 34866-47-2
CAS Name: [5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]urea
Synonyms: a-(t-butylaminomethyl)-4-hydroxy-3-ureidobenzyl alcohol
Molecular Formula: C13H21N3O3
Molecular Weight: 267.32
Percent Composition: C 58.41%, H 7.92%, N 15.72%, O 17.96%
Literature References: A b-adrenergic agonist related to isoproterenol, q.v., with selectivity for airway smooth muscle receptors. Prepn: C. Kaiser, S. T. Ross, DE 2106620; eidem, US 3763232 (1971, 1973 both to SKF); C. Kaiser et al., J. Med. Chem. 17, 49 (1974). Pharmacology, mechanism of action, toxicity study: J. R. Wardell et al., J. Pharmacol. Exp. Ther. 189, 167 (1974). Analysis in aq soln: L. J. Ravin et al., J. Pharm. Sci. 67, 1523 (1978). Clinical study: T. D. James, H. A. Lyons, J. Am. Med. Assoc. 241, 704 (1979).
Properties: Crystals, mp 174-176°. LD50 in mice (mg/kg): 32.8 i.v.; 3134.6 orally; in rats: 77.2 i.v. (Wardell).
Melting point: mp 174-176°
Toxicity data: LD50 in mice (mg/kg): 32.8 i.v.; 3134.6 orally; in rats: 77.2 i.v. (Wardell)
 
Derivative Type: Hydrochloride
CAS Registry Number: 34866-46-1
Manufacturers' Codes: SKF-40383
Trademarks: Bronsecur (SK & F); Pirem (Gecke)
Molecular Formula: C13H21N3O3.HCl
Molecular Weight: 303.79
Percent Composition: C 51.40%, H 7.30%, N 13.83%, O 15.80%, Cl 11.67%
Properties: Crystals from ethanol/ether, mp 205-207° (dec).
Melting point: mp 205-207° (dec)
 
Therap-Cat: Bronchodilator.
Keywords: ?Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives.