Home > Name List By 6 > 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1, 3-dimethylpyrimidine-2,4-dione India

CAS No 34661-75-1 , 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,
3-dimethylpyrimidine-2,4-dione Search by region : India

  • Name: 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,
    3-dimethylpyrimidine-2,4-dione
  • Synonyms: Eupressyl; 34661-75-1; Urapidilum [INN-Latin]; Mediatensyl;Ebrantil; urapidil(jan); MLS003115907;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,
    3-dimethylpyrimidine-2,4-dione; B-66256; Uraprene;
  • CAS Registry Number:
  • Density: 1.26 g/cm3
  • Refractive index: 1.622
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Used as an antihypertensive agent.
  • EINECS: 252-130-4
  • Molecular Weight: 387.47596
  • InchiKey: ICMGLRUYEQNHPF-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-
    25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3
  • Molecular Formula: C20H29N5O3
  • Molecular Structure:CAS No:34661-75-1 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,<br />3-dimethylpyrimidine-2,4-dione

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34661-75-1 URAPIDIL-D4

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
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References of 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,
3-dimethylpyrimidine-2,4-dione
Title: Urapidil
CAS Registry Number: 34661-75-1
CAS Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
Synonyms: 6-[[3-[4-(o-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
Manufacturers' Codes: B-66256
Trademarks: Ebrantil (Byk Gulden); Eupressyl (Byk Gulden); Uraprene (IBI)
Molecular Formula: C20H29N5O3
Molecular Weight: 387.48
Percent Composition: C 61.99%, H 7.54%, N 18.07%, O 12.39%
Literature References: a1-Adrenergic antagonist; deriv of uracil, q.v. Prepn: W. Pruesse et al., DE 1942405; eidem, US 3957786 (1971, 1976 both to Byk Gulden); K. Klemm et al., Arzneim.-Forsch. 27, 1895 (1977). Series of articles on pharmacology, pharmacokinetics, metabolism: ibid. 1898-1932. Toxicity data: J. Koenig et al., ibid. 1919. Mode of action: M. Eltze, Eur. J. Pharmacol. 59, 1 (1979); H. R. Kaplan, R. D. Smith, Fed. Proc. 40, 2268 (1981). Hemodynamic responses in man: G. G. Belz et al., Clin. Pharmacol. Ther. 37, 48 (1985). Clinical trials: A. Barankay et al., Arzneim.-Forsch. 31, 849 (1981); H. Liebau et al., J. Hypertens. 4, Suppl. 6, S141 (1986). Series of articles on clinical efficacy in hypertension: Drugs 35, Suppl. 6, 147-192 (1988).
Properties: Crystals from water, mp 156-158°. uv max (methanol): 237, 268 nm (e 1.10′104, 2.67′104). pKa 7.10. LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig).
Melting point: mp 156-158°
pKa: pKa 7.10
Absorption maximum: uv max (methanol): 237, 268 nm (e 1.10′104, 2.67′104)
Toxicity data: LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.