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CAS No 34031-32-8 , AURANOFIN Search by region : China

  • Name: AURANOFIN
  • Synonyms: AURANOFIN;(1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate;
  • CAS Registry Number:
  • Melting Point: 103 - 105
  • Flash Point: 298°C
  • Boiling Point: 425.5°Cat760mmHg
  • Density: g/cm3
  • Safety Statements: Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: ulceration or bleeding from stomach. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and POx. See also GOLD COMPOUNDS.
  • Flash Point: 298°C
  • EINECS: 251-801-9
  • Molecular Weight: 678.48
  • InChI: InChI=1/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1/rC20H34AuO9PS/c1-8-31(9-2,10-3)21-32-20-19(29-15(7)25)18(28-14(6)24)17(27-13(5)23)16(30-20)11-26-12(4)22/h16-20H,8-11H2,1-7H3/t16-,17-,18+,19-,20+/m1/s1
  • Molecular Formula: C20H34AuO9PS
  • Molecular Structure:CAS No:34031-32-8 AURANOFIN

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References of AURANOFIN
Title: Auranofin
CAS Registry Number: 34031-32-8
CAS Name: (1-Thio-b-D-glucopyranose-2,3,4,6-tetraacetato-S)(triethylphosphine)gold
Synonyms: (2,3,4,6-tetra-O-acetyl-1-thio-b-D-glucopyranosato-S)(triethylphosphine)gold; (1-thio-b-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
Manufacturers' Codes: SKF-39162
Trademarks: Crisinor (Rubio); Crisofin (Allergan); Ridaura (Prometheus); Ridauran (Robapharm)
Molecular Formula: C20H34AuO9PS
Molecular Weight: 678.48
Percent Composition: C 35.40%, H 5.05%, Au 29.03%, O 21.22%, P 4.57%, S 4.73%
Literature References: Disease modifying antirheumatic drug (DMARD); orally active gold coordination complex. Prepn: E. R. McGusty, B. M. Sutton, DE 2051495; eidem, US 3635945 (1971, 1972 both to SKF). Toxicity study: B. H. Payne, D. T. Walz, Vet. Pathol. 15, Suppl. 5, 1 (1978). HPLC determn in urine: R. Kizu et al., Chem. Pharm. Bull. 41, 1261 (1993). Symposium on pharmacology and clinical experience: J. Rheumatol. 9, Suppl. 8, 1-209 (1982). Clinical trial in rheumatoid arthritis: M. Itokazu et al., Clin. Ther. 17, 60 (1995); in steroid-dependent asthma: I. L. Bernstein et al., J. Allergy Clin. Immunol. 98, 317 (1996). Review: W. F. Kean et al., Br. J. Rheumatol. 36, 560-572 (1997).
Properties: White, odorless, crystalline powder, mp 112-115°. Insol in water. Unstable to light and heat. LD50 in rats, mice (mg/kg): 265, 310 orally (Payne, Walz).
Melting point: mp 112-115°
Toxicity data: LD50 in rats, mice (mg/kg): 265, 310 orally (Payne, Walz)
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic.