Title: Panitumumab
CAS Registry Number: 339177-26-3
CAS Name: Anti-(human epidermal growth factor receptor) immunoglobulin (human monoclonal ABX-EGF heavy chain) disulfide with human monoclonal ABX-EGF light chain, dimer
Synonyms: ABX-EGF
Literature References: Fully human monoclonal antibody secreted by the E7.6.3 hybridoma; directed against human epidermal growth factor receptor (EGFr), a transmembrane cell-surface glycoprotein overexpressed in a variety of cancers. Prepn: A. Jakobovits
et al.,
WO 9850433;
eidem,
US 6235883 (1998, 2001 both to Abgenix); and
in vivo antitumor activity: X.-D. Yang
et al.,
Cancer Res. 59, 1236 (1999). Clinical pharmacokinetics: E. K. Rowinsky
et al., J. Clin. Oncol. 22, 3003 (2004). Review of preclinical and clinical evaluations: K. A. Foon
et al.,
Int. J. Radiat. Oncol. Biol. Phys. 58, 984-990 (2004).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Monoclonal Antibodies.
