CAS No 3371-85-5 , Voacamine

Name: Voacamine
Synonyms: VOACAMINE;NSC 82591;Ibogamine-18-carboxylic acid, 12-methoxy-13-((3alpha)-17-methoxy-17-oxovobasan-3-yl)-, methyl ester (9CI);12-Methoxy-13-((3alpha)-17-methoxy-17-oxovobasan-3-yl)ibogamine-18-carboxylic acid methyl ester;Crystalline compound from Voacanga afracina;Vocamine;Voacamine (8CI);B 606109;6,9-Methano-5H-pyrido(1',2':1,2)azepino(4,5-b)indole-6-carboxylic;methyl (2alpha)-12-methoxy-13-[(3alpha,5alpha,19E)-17-methoxy-17-oxovobasan-3-yl]ibogamine-18-carboxylate;Voacanginine;Voacamine;Methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate;methyl 12-methoxy-13-[(3alpha,19Z)-17-methoxy-17-oxovobasan-3-yl]ibogamine-18-carboxylate;
CAS Registry Number:3371-85-5
Flash Point: °C
Boiling Point: °Cat760mmHg
Density: 1.309g/cm³
Refractive index: 1.674
Flash Point: °C
EINECS: 222-151-3
Molecular Weight: 704.8968
InChI: InChI=1/C43H52N4O5/c1-7-24-15-23-20-43(42(49)52-6)39-27(13-14-47(21-23)40(24)43)29-19-36(50-4)30(17-34(29)45-39)31-16-28-25(8-2)22-46(3)35(37(28)41(48)51-5)18-32-26-11-9-10-12-33(26)44-38(31)32/h8-12,17,19,23-24,28,31,35,37,40,44-45H,7,13-16,18,20-22H2,1-6H3/b25-8-/t23-,24-,28-,31+,35+,37?,40-,43+/m0/s1
Molecular Formula: C₄₃H₅₂N₄O₅
Molecular Structure:

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3371-85-5 VOACAMINE

Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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3371-85-5 VOACAMINE

Cfm Oskar Tropitzsch [Manufacturer]
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References of Voacamine

Title: Voacamine
CAS Registry Number: 3371-85-5
CAS Name: 12-Methoxy-13-[(3a)-17-methoxy-17-oxovobasan-3-yl]ibogamine-18-carboxylic acid methyl ester
Synonyms: voacanginine
Molecular Formula: C43H52N4O5
Molecular Weight: 704.90
Percent Composition: C 73.27%, H 7.44%, N 7.95%, O 11.35%
Literature References: Bisindole alkaloid found in Voacanga africana Stapf., V. thouarsii R. & Sch., var obtusa (K. Sch.) Pichon and V. schweinfurthii Staph., Apocynaceae: Janot, Goutarel, Compt. Rend. 240, 1719 (1955); Rao, J. Org. Chem. 23, 1455 (1958); Janot, Goutarel, US 2823204 (1958 to Lab. Gobey). Identity with voacanginine: LeBarre, Gillo, Bull. Acad. R. Med. Belg. 20, 194 (1956). Cleaved by acid catalysis to voacangine: Winkler, Naturwissenschaften 48, 694 (1961). Structure: Goutarel et al., Compt. Rend. 243, 1670 (1956); Percheron, Ann. Chim. (Paris) 4, 303 (1959); Büchi et al., J. Am. Chem. Soc. 85, 1893 (1963). Review: Gorman et al. in The Alkaloids 1, J. E. Saxton, Ed. (The Chem. Soc., London, 1971) pp 242-249.
Properties: Prisms from acetone + methanol, dec 223°. [a]D20 -52° (chloroform). uv max: 225, 295 nm (log e 4.72, 4.28). Sol in chloroform, acetone; slightly sol in methanol, ethanol.
Optical Rotation: [a]D20 -52° (chloroform)
Absorption maximum: uv max: 225, 295 nm (log e 4.72, 4.28)

Derivative Type: Voacangine
Synonyms: Carbomethoxyibogaine; 12-methoxyibogamine-18-carboxylic acid methyl ester
Molecular Formula: C22H28N2O3
Molecular Weight: 368.47
Percent Composition: C 71.71%, H 7.66%, N 7.60%, O 13.03%
Literature References: Structure: Bartlett et al., J. Am. Chem. Soc. 80, 126 (1958).
Properties: Prismatic needles from ethanol, mp 136-137°. Sublimes0.01 135°. [a]D20 -42° (c = 1.26 in chloroform). pKa 7.4 (40% aq methanol); pKa 5.73 (33% DMF). uv max (methanol): 225, 287 300 nm (log e 4.43, 3.97, 3.93). Freely sol in acetone, chloroform; slightly sol in methanol, ethanol.
Melting point: mp 136-137°
pKa: pKa 7.4 (40% aq methanol); pKa 5.73 (33% DMF)
Optical Rotation: [a]D20 -42° (c = 1.26 in chloroform)
Absorption maximum: uv max (methanol): 225, 287 300 nm (log e 4.43, 3.97, 3.93)