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CAS No 33419-42-0 , Etoposide Search by region : Switzerland

  • Name: Etoposide
  • Synonyms: TENIPOSIDE; 4-Demethylepipodophyllotoxin-beta-D-ethylideneglucoside; 4-demethylepipodophyllotoxin-beta-d-ethylideneglucoside; 4'-demethylepipodophyllotoxin-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside);Etoposide;4'-Demethylepipodophyllotoxin-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside);
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 236-251 ºC
  • Density: 1.55 g/cm3
  • Refractive index: -110.5 ° (C=0.6, CHCl3)
  • Water Solubility: DMSO: 30 mg/mL
  • Safety Statements: R45;R22
  • Hazard Symbols: T: Toxic;
  • EINECS: 251-509-1
  • Molecular Weight: 588.56
  • InChI: InChI=1/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
  • Risk Statements: S53;S45
  • Molecular Formula: C29H32O13
  • Molecular Structure:CAS No:33419-42-0 Etoposide

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33419-42-0 Etoposide

  • Etoposide, 99.7%
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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References of Etoposide
Title: Etoposide
CAS Registry Number: 33419-42-0
CAS Name: 9-[(4,6-O-Ethylidene-b-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3￠,4￠:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Synonyms: 4￠-demethylepipodophyllotoxin 9-[4,6-O-ethylidene-b-D-glucopyranoside]; EPEG
Manufacturers' Codes: NSC-141540; VP-16-213
Trademarks: Lastet (Nippon Kayaku); Vepesid (BMS)
Molecular Formula: C29H32O13
Molecular Weight: 588.56
Percent Composition: C 59.18%, H 5.48%, O 35.34%
Literature References: DNA topoisomerase II inhibitor. Semi-synthetic deriv of podophyllotoxin, related structurally to teniposide, q.q.v. Prepn: C. Keller-Juslén et al., US 3524844 (1970 to Sandoz); idem et al., J. Med. Chem. 14, 936 (1971). Teratogenicity and cytogenicity study: S. M. Sieber et al., Teratology 18, 31 (1978). Review of pharmacokinetics and assay methods: P. I. Clark, M. L. Slevin, Clin. Pharmacokinet. 12, 223-252 (1987). Comprehensive description: J. J. M. Holthuis et al., Anal. Profiles Drug Subs. 18, 121-151 (1989). Review of pharmacology and clinical experience: J. D. Hainsworth, F. A. Greco, Ann. Oncol. 6, 325-341 (1995); S. Joel, Cancer Treat. Rev. 22, 179-221 (1996).
Properties: Crystals from methanol, mp 236-251°. [a]D20 -110.5° (c = 0.6 in chloroform). uv max (abs methanol): 283 nm (e 4245). pKa 9.8. Very sol in methanol, chloroform; slightly sol in ethanol; sparingly sol in water.
Melting point: mp 236-251°
pKa: pKa 9.8
Optical Rotation: [a]D20 -110.5° (c = 0.6 in chloroform)
Absorption maximum: uv max (abs methanol): 283 nm (e 4245)
 
Derivative Type: Phosphate
CAS Registry Number: 117091-64-2
Manufacturers' Codes: BMY-40481
Trademarks: Etopophos (BMS)
Molecular Formula: C29H33O16P
Molecular Weight: 668.54
Percent Composition: C 52.10%, H 4.98%, O 38.29%, P 4.63%
Literature References: Review: A. H. I. Witterland et al., Pharm. World Sci. 18, 163-170 (1996).
Properties: Sol in water. Practically insol in organic solvents.
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Podophyllum Derivatives; Topoisomerase II Inhibitor.