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CAS No 328538-04-1 , DNA,d(P-thio)(C-T-A-G-A-T-T-T-C-C-C-G-C-G), complex with DNAd(P-thio)(G-A-T-C-C-G-C-G-G-G-A-A-A-T) (1:1), hexacosasodium salt (9CI)

  • Name: DNA,d(P-thio)(C-T-A-G-A-T-T-T-C-C-C-G-C-G), complex with DNAd(P-thio)(G-A-T-C-C-G-C-G-G-G-A-A-A-T) (1:1), hexacosasodium salt (9CI)
  • Synonyms: DNA,d(P-thio)(C-T-A-G-A-T-T-T-C-C-C-G-C-G), complex with DNAd(P-thio)(G-A-T-C-C-G-C-G-G-G-A-A-A-T) (1:1), hexacosasodium salt (9CI); Edifoligide;CGT 003;E2F Duplex Decoy; Edifoligide sodium;
  • CAS Registry Number:
  • Molecular Weight: 0

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328538-04-1 Edifoligide

  • Edifoligide, Min 99%
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328538-04-1 EDIFOLGIDUM

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References of DNA,d(P-thio)(C-T-A-G-A-T-T-T-C-C-C-G-C-G), complex with DNAd(P-thio)(G-A-T-C-C-G-C-G-G-G-A-A-A-T) (1:1), hexacosasodium salt (9CI)
Title: Edifoligide Sodium
CAS Registry Number: 328538-04-1
CAS Name: DNA d(P-Thio)(C-T-A-G-A-T-T-T-C-C-C-G-C-G) complex with DNA d(P-thio)(G-A-T-C-C-G-C-G-G-G-A-A-A-T)(1:1) hexacosasodium salt
Synonyms: E2F Decoy; E2FD
Manufacturers' Codes: CGT-003
Literature References: Double stranded oligodeoxynucleotide designed to bind and inactivate the cell-cycle transcription factor E2F. Transcription factor decoy used in ex vivo gene suppression therapy to prevent vein graft failure following coronary artery and peripheral artery bypass surgery. Description of sequence and use as decoy: V. J. Dzau et al., WO 9511687; eidem, US 02052333 (1995, 2002). Binding inhibition study in vascular smooth muscle: R. Morishita et al., Proc. Natl. Acad. Sci. USA 92, 5855 (1995); in glomerular mesangial cells: N. Tomita et al., Am. J. Physiol. 275, F278 (1998). Pharmacology: A. Ehsan et al., J. Thorac. Cardiovasc. Surg. 121, 714 (2001). Clinical evaluation in vascular bypass: M. J. Mann et al., Lancet 354, 1493 (1999). Review of mechanism of action: M. J. Mann, Antisense Nucl. Acid Drug Dev. 8, 171-176 (1998).
Therap-Cat: Gene suppression therapy to prevent vein graft atherosclerosis.