Home > Name List By 4 > 4-(3-chloro-4-cyclohexylphenyl)-4-oxobutanoic acid

CAS No 32808-51-8 , 4-(3-chloro-4-cyclohexylphenyl)-4-oxobutanoic acid

  • Name: 4-(3-chloro-4-cyclohexylphenyl)-4-oxobutanoic acid
  • Synonyms: l'Acide bucloxique [French]; Acido bucloxico [INN-Spanish]; Bucloxonic acid; Acide bucloxique [INN-French];Esfar; Bucloxinsaeure [German];4-(3-chloro-4-cyclohexylphenyl)-4-oxobutanoic acid;
  • CAS Registry Number:
  • Flash Point: 245.3°C
  • Boiling Point: 482°Cat760mmHg
  • Density: 1.219g/cm3
  • Refractive index: 1.557
  • Safety Statements: Poison by intraperitoneal and ingestion routes. Experimental teratogenic and reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of Cl−.
  • Flash Point: 245.3°C
  • EINECS: 251-231-0
  • Molecular Weight: 294.77326
  • InchiKey: IJTPQQVCKPZIMV-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H19ClO3/c17-14-10-12(15(18)8-9-16(19)20)6-7-13(14)11-4-2-1-
    3-5-11/h6-7,10-11H,1-5,8-9H2,(H,19,20)
  • Molecular Formula: C16H19ClO3
  • Molecular Structure:CAS No:32808-51-8 4-(3-chloro-4-cyclohexylphenyl)-4-oxobutanoic acid

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References of 4-(3-chloro-4-cyclohexylphenyl)-4-oxobutanoic acid
Title: Bucloxic Acid
CAS Registry Number: 32808-51-8
CAS Name: 3-Chloro-4-cyclohexyl-a-oxobenzenebutanoic acid
Synonyms: 3-(3-chloro-4-cyclohexylbenzoyl)propionic acid; 4-(4-cyclohexyl-3-chlorophenyl)-4-oxobutyric acid; bucloxonic acid
Molecular Formula: C16H19ClO3
Molecular Weight: 294.77
Percent Composition: C 65.19%, H 6.50%, Cl 12.03%, O 16.28%
Literature References: Prepn: Krausz, Brunaud, DE 2021445 (1970 to Clin-Byla), C.A. 75, 5521d (1971); GB 1315542; Krausz et al., Arzneim.-Forsch. 24, 1360, 1364 (1974). Series of articles on pharmacology, metabolism, toxicity: ibid. 1368-1444. Toxicology: G. Mauzé et al., ibid. 1398.
Properties: Crystals from acetone, mp 163°. uv max (ethanol): 255 nm (e 15,500). LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360).
Melting point: mp 163°
Absorption maximum: uv max (ethanol): 255 nm (e 15,500)
Toxicity data: LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360)
 
Derivative Type: Calcium salt
CAS Registry Number: 32808-53-0
Manufacturers' Codes: CB-804
Trademarks: Esfar
Molecular Formula: C32H36CaCl2O6
Molecular Weight: 627.61
Percent Composition: C 61.24%, H 5.78%, Ca 6.39%, Cl 11.30%, O 15.30%
Properties: LD50 in male, female mice, rats (mg/kg): 1558, 1697, 195, 600-900 i.p.; 852, 1656, 176, 649 orally (Mauzé).
Toxicity data: LD50 in male, female mice, rats (mg/kg): 1558, 1697, 195, 600-900 i.p.; 852, 1656, 176, 649 orally (Mauzé)
 
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.