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CAS No 31883-05-3 , ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate

  • Name: ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate
  • Synonyms: Moracizinum; Ethmozine; EN-313; Moricizine [USAN];ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate; Moracizina [INN-Spanish]; Moracizina; Moracizin; Moracizinum [INN-Latin];Moracizine;
  • CAS Registry Number:
  • Flash Point: 331.8°C
  • Boiling Point: 625°C at 760 mmHg
  • Density: 1.315g/cm3
  • Refractive index: 1.639
  • Flash Point: 331.8°C
  • EINECS: 250-854-5
  • Molecular Weight: 427.5166
  • InchiKey: FUBVWMNBEHXPSU-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-
    19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,
    27)
  • Molecular Formula: C22H25N3O4S
  • Molecular Structure:CAS No:31883-05-3 ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate

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31883-05-3 moricizine

  • IUPAC NAME-ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate MOLECULAR FORMULA-C22H25N3O4S MOLAR MASS-427.518 g/mol
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31883-05-3 Moracizine

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31883-05-3 MORACIZINE

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References of ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate
Title: Moricizine
CAS Registry Number: 31883-05-3
CAS Name: [10-[3-(4-Morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]carbamic acid ethyl ester
Synonyms: 10-(3-morpholinopropionyl)phenothiazine-2-carbamic acid ethyl ester; ethmosine; ethmozin; moracizine
Manufacturers' Codes: EN-313
Molecular Formula: C22H25N3O4S
Molecular Weight: 427.52
Percent Composition: C 61.81%, H 5.89%, N 9.83%, O 14.97%, S 7.50%
Literature References: Sodium channel blocker. Prepn: A. Gritsenko et al., DE 2014201 (1971 to Acad. Med. Sci., USSR), C.A. 76, 34273a (1972); eidem, US 3740395 (1973). Pharmacology and toxicity: N. V. Kaverina et al., Russ. Pharmacol. Toxicol. 35, 74 (1972). Mechanism of action study: T. Yamane et al., Br. J. Pharmacol. 108, 812 (1993). HPLC determn in plasma: C. C. Whitney et al., J. Pharm. Sci. 70, 462 (1981). Symposium on pharmacology, pharmacokinetics, clinical safety and efficacy: Am. J. Cardiol. 65, 1D-71D (1990). Review: C. A. Clyne et al., N. Engl. J. Med. 327, 255 (1992).
Properties: Crystals, mp 156-157°. pKa 6.4.
Melting point: mp 156-157°
pKa: pKa 6.4
 
Derivative Type: Hydrochloride
CAS Registry Number: 29560-58-5
Trademarks: Ethmozine (Roberts)
Molecular Formula: C22H25N3O4S.HCl
Molecular Weight: 463.98
Percent Composition: C 56.95%, H 5.65%, N 9.06%, O 13.79%, S 6.91%, Cl 7.64%
Properties: Crystals from dichloroethane, mp 189° (dec). Sol in water, alcohol. LD50 in mice, rats (mg/kg): 36, 12 i.v.; in mice (mg/kg): 131 i.p. (Kaverina).
Melting point: mp 189° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 36, 12 i.v.; in mice (mg/kg): 131 i.p. (Kaverina)
 
Therap-Cat: Antiarrhythmic (class I).
Keywords: Antiarrhythmic.