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CAS No 315-30-0 , 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one

  • Name: 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one
  • Synonyms: Embarin; Uripurinol; Atisuril; Foligan; Lopurin;Zyloprim;1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one; Zyloric; Bleminol; Milurit;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 350 ºC
  • Density: 1.89g/cm3
  • Refractive index: 1.816
  • Water Solubility: 0.35 G/L (25 ºC)
  • Safety Statements: R25;R36/37/38;R43
  • Hazard Symbols: T: Toxic;
  • EINECS: 206-250-9
  • Molecular Weight: 136.11146
  • InchiKey: OFCNXPDARWKPPY-UHFFFAOYSA-N
  • InChI: InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
  • Risk Statements: S24;S26;S36/37/39;S45
  • Molecular Formula: C5H4N4O
  • Molecular Structure:CAS No:315-30-0 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one

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References of 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one
Title: Allopurinol
CAS Registry Number: 315-30-0
CAS Name: 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Synonyms: 1H-pyrazolo[3,4-d]pyrimidin-4-ol; 4-hydroxypyrazolo[3,4-d]pyrimidine; HPP
Manufacturers' Codes: BW-56158
Trademarks: Adenock (Mitsubishi); Allurit (Aventis); Aloral (Lagap); Alositol (Tanabe); Allo-Puren (Isis); Allozym (Sawai); Allural (Rovi); Anoprolin (Azwell); Anzief (Nippon Chemiphar); Apulonga (Dorsch); Apurol (Siegfried); Apurin (GEA); Bleminol (Gepepharm); Caplenal (Teva); Cellidrin (Hennig); Cosuric (DDSA); Dabroson (Hoyer); Embarin (Merckle); Epidropal (Teofarma); Foligan (DESMA); Gichtex (Gerot); Hamarin (Roche); Hexanurat (Durascan); Ketanrift (Ohta); Lopurin (Abbott); Lysuron (Roche); Miniplanor (Galen); Monarch (SS Pharm.); Remid (TAD); Riball (Schering AG); Sigapurol (Siegfried); Suspendol (Merckle); Takanarumin (Takata); Uricemil (Molteni); Uripurinol (Azupharma); Urosin (Roche); Urtias (Novartis); Zyloprim (GSK); Zyloric (GSK)
Molecular Formula: C5H4N4O
Molecular Weight: 136.11
Percent Composition: C 44.12%, H 2.96%, N 41.16%, O 11.75%
Literature References: Xanthine oxidase inhibitor; decreases uric acid production. Prepn: Robins, J. Am. Chem. Soc. 78, 784 (1956); Schmidt, Druey, Helv. Chim. Acta 39, 986 (1956); Druey, Schmidt, US 2868803 (1959 to Ciba); GB 798646 (1958 to Wellcome Found.); Hitchings, Falco, US 3474098 (1969 to Burroughs Wellcome). Physiological and biochemical studies: Hitchings, in Biochem. Aspects Antimetab. Drug Hydroxylation, D. Shugar, Ed. (Academic Press, London, 1969) pp 11-22, C.A. 75, 3531h (1971). Clinical trial in treatment of renal calculi: M. J. V. Smith, J. Urol. 117, 690 (1977); B. Ettinger et al., N. Engl. J. Med. 315, 1386 (1986). Use in hyperuricemia and gout: G. R. Boss, J. E. Seegmiller, ibid. 300, 1459 (1977). Effect on renal function in treatment of gout: T. Gibson, Ann. Rheum. Dis. 41, 59 (1982). Comprehensive description: S. A. Benezra, T. R. Bennett, Anal. Profiles Drug Subs. 7, 1-17 (1978).
Properties: Crystals, mp above 350°. uv max (0.1N NaOH): 257 nm (e 7200); (0.1N HCl): 250 nm (e 7600); (methanol): 252 nm (e 7600). Soly in mg/ml at 25°: water 0.48; n-octanol <0.01; chloroform 0.60; ethanol 0.30; DMSO 4.6. pKa 10.2.
Melting point: mp above 350°
pKa: pKa 10.2
Absorption maximum: uv max (0.1N NaOH): 257 nm (e 7200); (0.1N HCl): 250 nm (e 7600); (methanol): 252 nm (e 7600)
 
Derivative Type: Sodium salt
CAS Registry Number: 17795-21-0
Trademarks: Aloprim (Nabi)
Molecular Formula: C5H3N4NaO
Molecular Weight: 158.09
Percent Composition: C 37.99%, H 1.91%, N 35.44%, Na 14.54%, O 10.12%
Properties: White amorphous mass. pKa 9.31.
pKa: pKa 9.31
 
Therap-Cat: Treatment of hyperuricemia and chronic gout. Antiurolithic.
Keywords: Antigout; Antiurolithic; Xanthine Oxidase Inhibitor.