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CAS No 3094-09-5 , Doxifluridine

  • Name: Doxifluridine
  • CAS Registry Number:
  • Melting Point: 188-192 °C
  • Density: 1.63g/cm3
  • Refractive index: 20 ° (C=1, H2O)
  • Safety Statements: Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F− and NOx.
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 221-440-1
  • Molecular Weight: 246.19
  • InChI: InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C9H11FN2O5
  • Molecular Structure:CAS No:3094-09-5 Doxifluridine

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References of Doxifluridine
Title: Doxifluridine
CAS Registry Number: 3094-09-5
CAS Name: 5￠-Deoxy-5-fluorouridine
Synonyms: 1-(b-D-5￠-deoxyribofuranosyl)-5-fluorouracil; 5￠-DFUR; 5￠-dFUrd
Manufacturers' Codes: Ro-21-9738
Trademarks: Flutron (Roche); Furtulon (Roche)
Molecular Formula: C9H11FN2O5
Molecular Weight: 246.19
Percent Composition: C 43.91%, H 4.50%, F 7.72%, N 11.38%, O 32.49%
Literature References: Fluorinated pyrimidine nucleoside with cytostatic activity. Prepn: A. F. Cook, US 4071680 (1978 to Hoffmann-La Roche); H. Hrebabecky, J. Beranek, Nucleic Acids Res. 5, 1029 (1978); A. F. Cook et al., J. Med. Chem. 22, 1330 (1979). Stereospecific synthesis: J. Kiss et al., Helv. Chim. Acta 65, 1522 (1982). Mechanism of action studies: H.-R. Hartmann, A. Matter, Cancer Res. 42, 2412 (1982); R. D. Armstrong et al., Cancer Chemother. Pharmacol. 11, 102 (1983). Kinetics and metabolism in humans: J.-P. Sommadossi et al., Cancer Res. 43, 930 (1983). Clinical trials in colorectal carcinoma: R. Abele et al., J. Clin. Oncol. 1, 750 (1983); S. D. Fossa et al., Cancer Chemother. Pharmacol. 15, 161 (1985). Series of articles on animal toxicology: Yakuri to Chiryo 13, Suppl. 2, 221-430 (1985); acute toxicity: M. Shimizu et al., ibid. 209, C.A. 104, 14673z-14678e (1986). Evaluation of neurotoxicity in humans: M. S. Heier, S. D. Fossa, Acta Neurol. Scand. 73, 449 (1986).
Properties: Crystals from ethyl acetate, mp 189-190° (Cook). Also reported as crystals from 2-propanol, mp 186-188° (Hrebabecky, Beranek); needles from methanol + ethyl acetate, mp 192-193° (Kiss). pKa 7.4. [a]D25 +18.4° (c = 0.419 in water). uv max (in methanol): 268-269 nm (e 8550). LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu).
Melting point: mp 189-190° (Cook); mp 186-188° (Hrebabecky, Beranek); mp 192-193° (Kiss)
pKa: pKa 7.4
Optical Rotation: [a]D25 +18.4° (c = 0.419 in water)
Absorption maximum: uv max (in methanol): 268-269 nm (e 8550)
Toxicity data: LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs.