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CAS No 30652-11-0 , 3-hydroxy-1,2-dimethylpyridin-4-one Search by region : China

  • Name: 3-hydroxy-1,2-dimethylpyridin-4-one
  • Synonyms: 1,2-Dimethyl-3-hydroxypyrid-4-one; Deferiprone (INN); CP20; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone; APO-066;Ferriprox; 30652-11-0;3-hydroxy-1,2-dimethylpyridin-4-one;
  • CAS Registry Number:
  • Melting Point: 271-273 ºC
  • Density: 1.225 g/cm3
  • Refractive index: 1.564
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 212-783-8
  • Molecular Weight: 139.15186
  • InchiKey: TZXKOCQBRNJULO-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
  • Risk Statements: S26;S37/39
  • Molecular Formula: C7H9NO2
  • Molecular Structure:CAS No:30652-11-0 3-hydroxy-1,2-dimethylpyridin-4-one

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30652-11-0 Deferiprone

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China null,nullChina
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30652-11-0 Deferiprone

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30652-11-0 Enalapril maleate

  • Enalapril maleate
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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30652-11-0 Enalapril maleate

  • Enalapril maleate, 97%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 null,nullChina
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30652-11-0 Enalapril Maleate EPIII

  • Enalapril Maleate EPIIIS)-1-[N-[1-(ethoxycarbonyl) -3-phenylpropyl]-L-alanyl] -L-proline, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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30652-11-0 Deferiprone

  • Deferiprone
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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30652-11-0 Enalapril maleate

  • Enalapril maleateEnalapril maleate, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,nullChina
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30652-11-0 Enalapril maleate

  • Enalapril maleate, 98%
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
  • Fax: +86-21-64968086
  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,nullChina
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30652-11-0 Enalapril Maleate

  • Enalapril Maleate, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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30652-11-0 Deferiprone

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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References of 3-hydroxy-1,2-dimethylpyridin-4-one
Title: Deferiprone
CAS Registry Number: 30652-11-0
CAS Name: 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone
Synonyms: 1,2-dimethyl-3-hydroxypyrid-4-one; DMHP; L1
Manufacturers' Codes: CP-20
Trademarks: Kelfer (Cipla)
Molecular Formula: C7H9NO2
Molecular Weight: 139.15
Percent Composition: C 60.42%, H 6.52%, N 10.07%, O 23.00%
Literature References: Orally active chelator that promotes urinary iron excretion. Prepn: M. Yasue et al., Yakugaku Zasshi 90, 1222 (1970), C.A. 74, 23102b (1971); G. J. Kontoghiorghes et al., Arzneim.-Forsch. 37, 1099 (1987). Iron binding studies: idem, Inorg. Chim. Acta 135, 145 (1987). HPLC determn in serum and urine: B. Dresow et al., J. Anal. Chem. 352, 562 (1995). Clinical pharmacokinetics: F. N. Al-Refaie et al., Br. J. Haematol. 89, 403 (1995). Clinical studies in transfusional iron overload: idem et al., ibid. 91, 224 (1995); N. F. Olivieri et al., N. Engl. J. Med. 332, 918 (1995). Review of pharmacology and clinical experience: G. J. Kontoghiorghes, Ann. N.Y. Acad. Sci. 612, 339-350 (1990); F. N. Al-Refaie, A. V. Hoffbrand, Baill. Clin. Haematol. 7, 941-963 (1994); of toxicology: G. J. Kontoghiorghes, Toxicol. Lett. 80, 1-18 (1995).
Properties: Needles from water, mp 266-268° (Yasue); also reported as mp 263-266° (Kontoghiorghes et al., 1987). Very bitter taste. Soly at 37° (mg/ml): water ~20 (pH 7.4). pKa1 3.3, pKa2 9.7. uv max (phosphate buffer saline, pH 7.3): 460 nm (e 3600). Hydrophilic chelator; forms red colored complexes with iron. LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995).
Melting point: mp 266-268° (Yasue); mp 263-266° (Kontoghiorghes et al., 1987)
pKa: pKa1 3.3, pKa2 9.7
Absorption maximum: uv max (phosphate buffer saline, pH 7.3): 460 nm (e 3600)
Toxicity data: LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
Therap-Cat: Chelating agent (iron and aluminum).
Keywords: Chelating Agent.