Home > Name List By 3 > 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N, N-dimethylpropan-1-amine

CAS No 303-49-1 , 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,
N-dimethylpropan-1-amine

  • Name: 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,
    N-dimethylpropan-1-amine
  • Synonyms: 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,
    N-dimethylpropan-1-amine;Chlorimipramine; 3-Chloroimipramine; 303-49-1; Anafranil base; Anafranil (free base); Hydiphen; Chlomipramine; Monochlorimipramine;
  • CAS Registry Number:
  • Density: 1.119 g/cm3
  • Refractive index: 1.581
  • Water Solubility: H2O: 25 mg/mL
  • Safety Statements: Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and intravenous routes: convulsions, heart damage, and blood pressure increase, nausea or vomiting. Human teratogenic effects on the cardiovascular system of the fetus. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 206-144-2
  • Molecular Weight: 314.85232
  • InchiKey: GDLIGKIOYRNHDA-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17
    (20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
  • Risk Statements: 20/21/22
  • Molecular Formula: C19H23ClN2
  • Molecular Structure:CAS No:303-49-1 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,<br />N-dimethylpropan-1-amine

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References of 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,
N-dimethylpropan-1-amine
Title: Clomipramine
CAS Registry Number: 303-49-1
CAS Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
Synonyms: 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 5-(g-dimethylaminopropyl)-3-chloroiminodibenzyl; chlorimipramine
Manufacturers' Codes: G-34586
Molecular Formula: C19H23ClN2
Molecular Weight: 314.85
Percent Composition: C 72.48%, H 7.36%, Cl 11.26%, N 8.90%
Literature References: Serotonin reuptake inhibitor. Prepn: P. N. Craig et al., J. Org. Chem. 26, 135 (1961); W. Schindler, H. Dietrich, CH 371799; eidem, US 3467650 (1963, 1969 both to Geigy). Crystal and molecular structure of the hydrochloride: M. L. Post, A. S. Horn, Acta Crystallogr. 33B, 2590 (1977). HPLC determn in serum: H. Weigmann et al., J. Chromatogr. B 710, 227 (1998). Veterinary trial in canine compulsive disorder: C. J. Hewson et al., J. Am. Vet. Med. Assoc. 213, 1760 (1998); in canine separation anxiety: S. Petit et al., Rev. Med. Vet. 150, 133 (1999). Review of pharmacology and clinical experience in obsessive-compulsive disorder and depression: M. D. Peters et al., Clin. Pharm. 9, 165-178 (1990).
Properties: bp0.3 160-170°.
Boiling point: bp0.3 160-170°
 
Derivative Type: Hydrochloride
CAS Registry Number: 17321-77-6
Trademarks: Anafranil (Novartis); Clomicalm (Novartis)
Molecular Formula: C19H23ClN2.HCl
Molecular Weight: 351.31
Percent Composition: C 64.96%, H 6.89%, Cl 20.18%, N 7.97%
Properties: Crystals from acetone-ether/methanol-ether, mp 189-190° (Craig); also reported as crystals from acetone, mp 191.5-192° (Schindler, Dietrich). Freely sol in water, methanol, methylene chloride. Practically insol in ethyl ether, hexane.
Melting point: mp 189-190° (Craig); mp 191.5-192° (Schindler, Dietrich)
 
Therap-Cat: Antidepressant; antiobsessional agent.
Therap-Cat-Vet: In treatment of canine separation anxiety.
Keywords: Antidepressant; Tricyclics; Antiobsessional.