References of 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-ethyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide (1:1), (1a,2b,4b,5a,7b)-
Title: Oxitropium Bromide
CAS Registry Number: 30286-75-0
CAS Name: [7(
S)-(1a,2b,4b,5a,7b)]-9-Ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Synonyms: (8r)-6b,7b-epoxy-8-ethyl-3a-hydroxy-1a
H,5a
H-tropanium bromide (-)-tropate; (-)-
N-ethylnorscopolamine methobromide
Manufacturers' Codes: Ba-253; Ba-253-BR-L
Trademarks: Oxivent (Boehringer, Ing.); Tersigat (Boehringer, Ing.); Ventilat (Thomae)
Molecular Formula: C19H26BrNO4
Molecular Weight: 412.32
Percent Composition: C 55.35%, H 6.36%, Br 19.38%, N 3.40%, O 15.52%
Literature References: Anticholinergic bronchodilating agent. Prepn: K. Zeile
et al., US 3472861 (1969 to Boehringer, Ing.). Comparison with fenoterol,
q.v.: D. Nolte,
Respiration 36, 32 (1978); with ipratropium bromide,
q.v.: J. Lulling
et al., ibid. 42, 188 (1981). Efficacy in bronchial asthma: H. M. Beumer
et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 168 (1981); in exercise-induced asthma: K. Larsson,
Respiration 43, 57 (1982).
Properties: Crystals, mp 203-204° (dec). [a]D21 -25° (c = 2.0 in water).
Melting point: mp 203-204° (dec)
Optical Rotation: [a]D21 -25° (c = 2.0 in water)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Quaternary Ammonium Compounds; Antimuscarinic.