CAS No 30223-48-4 , 1-Propanone,3-(diethylamino)-1-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-

Name: 1-Propanone,3-(diethylamino)-1-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-
Synonyms: 1-Propanone,3-(diethylamino)-1-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-; Fluoracizine base; Ftoracizine;10H-Phenothiazine,10-[3-(diethylamino)-1-oxopropyl]-2-(trifluoromethyl)- (9CI); Fluoracizine; Phenothiazine,10-(N,N-diethyl-b-alanyl)-2-(trifluoromethyl)-(8CI); Fluacizine; Phtorazisin;
CAS Registry Number:30223-48-4
Transport: 3249
Flash Point: 273.5°C
Boiling Point: 528.6°Cat760mmHg
Density: 1.267g/cm³
Refractive index: 1.569
Safety Statements: Experimental teratogenic effects. When heated to decomposition it emits very toxic fumes of SO_x, NO_x, and F⁻.
Flash Point: 273.5°C
Molecular Weight: 394.49
InChI: InChI=1S/C20H21F3N2OS/c1-3-24(4-2)12-11-19(26)25-15-7-5-6-8-17(15)27-18-10-9-14(13-16(18)25)20(21,22)23/h5-10,13H,3-4,11-12H2,1-2H3
Molecular Formula: C20H21 F3 N2 O S
Molecular Structure:

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References of 1-Propanone,3-(diethylamino)-1-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-

Title: Fluacizine
CAS Registry Number: 30223-48-4
CAS Name: 10-[3-(Diethylamino)-1-oxopropyl]-2-(trifluoromethyl)-10H-phenothiazine
Synonyms: 10-(N,N-diethyl-b-alanyl)-2-(trifluoromethyl)phenothiazine; fluoracisine; fluoracizine; ftoracizine
Trademarks: Phtorazisin (Medexport)
Molecular Formula: C20H21F3N2OS
Molecular Weight: 394.45
Percent Composition: C 60.90%, H 5.37%, F 14.45%, N 7.10%, O 4.06%, S 8.13%
Literature References: Phenothiazine derivative with psychotropic activity. Prepn: Y. I. Vikhlyaev et al., SU 360342 (1972), C.A. 78, 97683w (1973); of hydrochloride: S. V. Zhuravlev et al., GB 1191800 (1970), C.A. 73, 25493h (1970); Y. I. Vikhlyaev et al., FR 2035748 (1971), C.A. 75, 140872j (1971); eidem, DE 1805659 (1979), C.A. 75, 49101w (1971). Use as antidepressant: eidem, SU 356992 (1972), C.A. 78, 75888q (1973) (all to Inst. Pharmacol. Chemother., Acad. Med. Sci., USSR). Mass spectrum: S. Morosawa et al., Org. Mass Spectrom. 17, 309 (1982). Effect on drug metabolism: V. Avakumov et al., Biochem. Pharmacol. 27, 2177 (1978). Pharmacokinetics in animals, man: V. P. Zherdev et al., Farmakol. Toksikol. (Moscow) 45, 83 (1982).

Derivative Type: Hydrochloride
Synonyms: Fluoracyzine; toracizin
Molecular Formula: C20H21F3N2OS.HCl
Molecular Weight: 430.91
Percent Composition: C 55.75%, H 5.15%, F 13.23%, N 6.50%, O 3.71%, S 7.44%, Cl 8.23%
Properties: White cryst powder, mp 163-165°. Sol in water, warm alcohols.
Melting point: mp 163-165°

Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.