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CAS No 29342-05-0 , 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Search by region : China

  • Name: 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
  • Synonyms: cyclopirox; Stieprox; Penlac; Terit;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one; 29342-05-0; Ciclopiroxum; Batrafen;Loprox; Ciclopiroxum [INN-Latin];
  • CAS Registry Number:
  • Melting Point: 144 ºC
  • Density: 1.193 g/cm3
  • Refractive index: 1.582
  • Water Solubility: soluble in methanol, ethanol or chloroform
  • EINECS: 249-577-2
  • Molecular Weight: 207.26888
  • InchiKey: SCKYRAXSEDYPSA-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,
    15H,2-6H2,1H3
  • Molecular Formula: C12H17NO2
  • Molecular Structure:CAS No:29342-05-0 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one

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References of 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
Title: Ciclopirox
CAS Registry Number: 29342-05-0
CAS Name: 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
Molecular Formula: C12H17NO2
Molecular Weight: 207.27
Percent Composition: C 69.54%, H 8.27%, N 6.76%, O 15.44%
Literature References: Broad spectrum antimycotic agent with some antibacterial activity. Prepn: G. Lohaus, W. Dittmar, ZA 6906039; eidem, US 3883545 (1970, 1975 both to Hoechst). In vitro study: eidem, Arzneim.-Forsch. 23, 670 (1973). Series of articles on pharmacokinetics, pharmacology, teratology, toxicity studies: Oyo Yakuri 9, 57-115 (1975), C.A. 83, 53159d, 53538b, 53539c, 71844c, 90833q (1975). Series of articles on chemistry, mechanism of action, toxicology, clinical trials: Arzneim.-Forsch. 31, 1309-1386 (1981). Toxicity data: H. G. Alpermann, E. Schutz, ibid. 1328. Review: S. G. Jue et al., Drugs 29, 330-341 (1985). Review of clinical experience in seborrheic dermatitis: A. Starova, R. Aly, Expert Opin. Drug Saf. 4, 235-239 (2005).
Properties: Solid, mp 144°.
Melting point: mp 144°
 
Derivative Type: Ethanolamine salt (1:1)
CAS Registry Number: 41621-49-2
Synonyms: Ciclopirox olamine
Manufacturers' Codes: HOE-296
Trademarks: Batrafen (HMR); Brumixol (Bruschettini); Ciclochem (Novag); Dafnegin (Poli); Loprox (HMR); Micoxolamina (Domp?; Mycoster (Fabre)
Molecular Formula: C14H24N2O3
Molecular Weight: 268.35
Percent Composition: C 62.66%, H 9.01%, N 10.44%, O 17.89%
Properties: LD50 in mice, rats (mg/kg): 2898, 3290 orally (Alpermann, Schutz).
Toxicity data: LD50 in mice, rats (mg/kg): 2898, 3290 orally (Alpermann, Schutz)
 
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic).