Home > Name List By n > N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

CAS No 27367-90-4 , N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

  • Name: N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide
  • Synonyms: Niaprazina [INN-Spanish];Nopron; Niaprazinum [INN-Latin]; BRN 0844157; 27367-90-4; EINECS 248-431-5; 1709 CERM;N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide;
  • CAS Registry Number:
  • Melting Point: 356.437
  • Flash Point: 303.3°C
  • Boiling Point: 577.9°Cat760mmHg
  • Density: 1.165g/cm3
  • Refractive index: 1.566
  • Flash Point: 303.3°C
  • EINECS: 248-431-5
  • Molecular Weight: 356.437103
  • InchiKey: RSKQGBFMNPDPLR-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25
    (14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)
  • Molecular Formula: C20H25FN4O
  • Molecular Structure:CAS No:27367-90-4 N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

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References of N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide
Title: Niaprazine
CAS Registry Number: 27367-90-4
CAS Name: N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide
Synonyms: N-[3-[4-(p-fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide
Trademarks: Nopron (Carrion)
Molecular Formula: C20H25FN4O
Molecular Weight: 356.44
Percent Composition: C 67.39%, H 7.07%, F 5.33%, N 15.72%, O 4.49%
Literature References: Prepn: R. Y. Mauvernay, DE 1957371 corresp to US 3712893 (1970, 1973 both to CERM). Pharmacology: P. Duchene-Marrullaz et al., Therapie 26, 1203 (1971). Psycholeptic effects in mice: J. Hache, J. Tachon, J. Pharmacol. 7, 469 (1976). Brain catecholamine depletion: P. E. Keane, M. S. Benedetti, Neuropharmacology 18, 595 (1979).
Properties: Cryst from ethyl acetate, mp 131°. Photosensitive. LD50 in mice (mg/kg): 890 orally, 145 i.v. (Mauvernay).
Melting point: mp 131°
Toxicity data: LD50 in mice (mg/kg): 890 orally, 145 i.v. (Mauvernay)
Therap-Cat: Sedative; hypnotic.
Keywords: Sedative/Hypnotic; Amides.