Home > Name List By 1 > 1-(3-hydroxy-4,7, 7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea

CAS No 26944-48-9 , 1-(3-hydroxy-4,7,
7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea

  • Name: 1-(3-hydroxy-4,7,
    7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea
  • Synonyms: Ro 6-4563; Glibornuridum [INN-Latin];Glutril; BRN 2821299; EINECS 248-124-6; Ro 6-4563/8; Glibornurida [INN-Spanish];1-(3-hydroxy-4,7,
    7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.3g/cm3
  • Refractive index: 1.6
  • Safety Statements: Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Flash Point: °C
  • EINECS: 248-124-6
  • Molecular Weight: 366.47504
  • InchiKey: RMTYNAPTNBJHQI-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H26N2O4S/c1-11-5-7-12(8-6-11)25(23,
    24)20-16(22)19-14-13-9-10-18(4,15(14)21)17(13,2)3/h5-8,13-15,21H,9-10H2,
    1-4H3,(H2,19,20,22)
  • Molecular Formula: C18H26N2O4S
  • Molecular Structure:CAS No:26944-48-9 1-(3-hydroxy-4,7,<br />7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea

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References of 1-(3-hydroxy-4,7,
7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea
Title: Glibornuride
CAS Registry Number: 26944-48-9
CAS Name: [1S-(endo,endo)]-N-[[(3-Hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Synonyms: (1R,2R,3S,4S)-1-(2-hydroxy-3-bornyl)-3-(p-tolylsulfonyl)urea; D-3-endo-p-tosylureidoborneol; 1-(p-tolylsulfonyl)-3-(2-endo-hydroxy-3-endo-D-bornyl)urea
Manufacturers' Codes: Ro-6-4563
Trademarks: Gluborid (Grñenthal); Glutril (Roche)
Molecular Formula: C18H26N2O4S
Molecular Weight: 366.48
Percent Composition: C 58.99%, H 7.15%, N 7.64%, O 17.46%, S 8.75%
Literature References: Prepn: H. Bretschneider et al., Monatsh. Chem. 100, 2133 (1969). See also: eidem, ZA 6706161; eidem, US 3770761; eidem, ZA 6902395; eidem, US 3654357 (1968, 1973, 1969, 1972, all to Hoffmann-La Roche). Comprehensive review of pharmacology: Arzneim.-Forsch. 22, 2153-2222 (1972).
Properties: Crystals, mp 192-195° (ethanol-water); also reported as 195-198°. [a]D +63.8° (ethanol).
Melting point: mp 192-195° (ethanol-water); also reported as 195-198°
Optical Rotation: [a]D +63.8° (ethanol)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.