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CAS No 26095-59-0 , diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium Search by region : France

  • Name: diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium
  • Synonyms: diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium;
    bromide; Ottilonio bromuro [Italian]; SP63;Otilonium Bromide; Octylonium bromide; Otilonii bromidum [INN-Latin]; Octylonium; 26095-59-0; Spasmomen;
  • CAS Registry Number:
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Br− and NOx.
  • EINECS: 247-457-4
  • Molecular Weight: 563.56672
  • InchiKey: VWZPIJGXYWHBOW-UHFFFAOYSA-N
  • InChI: InChI=1S/C29H42N2O4.BrH/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28
    (32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3;/h12-13,15-20H,
    5-11,14,21-23H2,1-4H3;1H
  • Molecular Formula: C29H43BrN2O4
  • Molecular Structure:CAS No:26095-59-0 diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium

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26095-59-0 OTILONIUM BROMIDE

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References of diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium
Title: Otilonium Bromide
CAS Registry Number: 26095-59-0
CAS Name: N,N-Diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium bromide
Synonyms: octylonium bromide
Manufacturers' Codes: SP-63
Trademarks: Doralin (Menarini); Menoctyl (Dong Wha); Pasminox (Beta); Spasen (Menarini); Spasmoctyl (Menarini); Spasmomen (Menarini)
Molecular Formula: C29H43BrN2O4
Molecular Weight: 563.57
Percent Composition: C 61.80%, H 7.69%, Br 14.18%, N 4.97%, O 11.36%
Literature References: Quaternary ammonium salt with gastrointestinal spasmolytic activity. Prepn: BE 704269; M. Ghelardoni et al., US 3536723 (1968, 1970 both to Menarini); idem et al., J. Med. Chem. 16, 1063 (1973). Determn of finished pharmaceutical forms by HPLC: C. Mannucci et al., J. Pharm. Sci. 82, 367 (1993); by CE: S. Furlanetto et al., Analyst 126, 1700 (2001). Receptor binding study: S. Lindqvust et al., Br. J. Pharmacol. 137, 1134 (2002). Clinical trial in irritable bowel syndrome: G. Battaglia et al., Aliment. Pharmacol. Ther. 12, 1003 (1998). Review of pharmacology and clinical efficacy: S. Evangelista, J. Int. Med. Res. 27, 207-222 (1999); comparative review of clinical studies: idem, Curr. Pharm. Des. 10, 3561-3568 (2004).
Properties: Crystals from ethanol, mp 166-168°. LD50 in mice (mg/kg) 87.0 i.p. (Ghelardoni, 1973).
Melting point: mp 166-168°
Toxicity data: LD50 in mice (mg/kg) 87.0 i.p.
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic; Antimuscarinic.